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XU Xuenong: [zh] 阿伐那非的制备方法, [fr] PROCÉDÉ DE PRÉPARATION DAVANAFIL, [en] AVANAFIL PREPARATION METHOD. SUZHOU MIRACPHARMA TECHNOLOGY, XU Xuenong, SUZHOU WISTONG INTELLECTUAL PROPERTY AGENCY, November 27, 2014: WO/2014/187273

[en] Disclosed is a method for preparing avanafil (I) by using cytosine as the starting material. The preparation steps comprise: using cytosine as the raw material, and enabling the cytosine to react with side chain 3-chlorine-4-Methoxybenzyl halogen, N-(2-methylpyrimidine) methanamide, and S-hydro ...


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TIAN GUANGHUI, LI JUNQI: [ZH] 阿伐那非的制备方法, [EN] Preparation method of avanafil. SUZHOU WANGSHAN WANGSHUI BIOMEDICAL, TOPHARMAN SHANGHAI, SHANDONG TOPHARMAN PHARMACEUTICAL, zhu mei li weiying, May 27, 2015: CN137651301

[EN] The invention relates to a preparation method of avanafil and a new compound provided in a preparation process. According to the method, 5-uracil carboxylic acid or an ester thereof is taken as the raw material, and the avanafil meeting the clinical requirements can be synthesized at a relative ...


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CAO MINGCHENG: [ZH] 阿伐那非的制备方法, [EN] Preparation method of avanafil. HEFEI CHUANGXIN MEDICAL TECHNOLOGY, sun yonggang, May 20, 2015: CN137635657

[EN] The invention discloses a preparation method of avanafil. The preparation method comprises the following steps: hydrolyzing a compound II by using alkali liquor to obtain a compound III; performing amidation reaction between the compound III and 2-aminomethyl pyrimidine hydrochloride in the pre ...


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ZHOU HONG, ZHANG HUI, YU SHANSHAN, LIU SHAOXIAN, YUAN GUOJUN: [ZH] 阿伐那非的制备方法, [EN] Avanafil preparation method. NANJING XIAOZHUANG UNIVERSITY, meng qiangsheng, April 22, 2015: CN133465406

[EN] The invention relates to an avanafil preparation method. The method comprises the steps that a hydrolysis reaction is carried out on 4-(3-chlorin-4-methoxy benzyl amino)-2-methylehio pyrimidine-5-carboxylic acid ethyl ester, namely a compound (2) to obtain 4-(3-chlorin-4-methylehio pyrimidine)- ...