1
Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel prodrugs. PG TXL Company, Arnold White & Durkee, November 2, 1999: US05977163 (219 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm ...


2
Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel prodrugs. PG TXL Company, Foley & Lardner, July 17, 2001: US06262107 (63 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm ...


3
Li Chun, Wallace Sidney, Yu Dong Fang, Yang David J: Water soluble paclitaxel prodrugs. Pg Txl Company, August 4, 1999: EP0932399-A1 (19 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm ...


4
De Bont Hendricus Barthelomeas, Haisma Hidde Jacob, Leenders Ruben Geradus George, de Vos Dick, Scheeren Johan Wilhelm: Novel paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy. Pharmachemie, July 2, 1997: EP0781778-A1 (12 worldwide citation)

The invention relates to novel, water-soluble paclitaxel prodrugs wherein paclitaxel is, through its 2'-hydroxyl functionality, connected to a cleavable spacer group, which is in turn attached to a preferably enzymatically cleavable sugar group. Such prodrugs are relatively non-toxic and can be used ...


5
Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel prodrugs. PG TXL Company, Foley & Lardner, June 10, 2008: US07384977

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune d ...


6
Li Chun, Wallace Sidney, Yu Dong Fang, Yang David J: Bioprecurseurs de paclitaxel solubles dans leau, Water soluble paclitaxel prodrugs. Pg Txl Company, Pg Txl Company, SMART & BIGGAR, September 18, 1997: CA2250295

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm ...


7
De Bont Hendricus Barthelomeas Andreas, Leenders Ruben Gerardus George, Scheeren Johan Wilhelm, Haisma Hidde Jacob, de Vos Dick: Promedicaments a base de paclitaxel; methode de preparation et utilisation en chimiotherapie selective, Novel paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy. Pharmachemie, Pharmachemie, GOWLING LAFLEUR HENDERSON, January 22, 2002: CA2192424

The invention relates to novel, water-soluble paclitaxel prodrugs wherein paclitaxel is, through its 2'-hydroxyl functionality, connected to a cleavable spacer group, which is in turn attached to a preferably enzymatically cleavable sugar group. Such prodrugs are relatively non-toxic and can be used ...


8
C Li, S Wallace, D F Yu: Water soluble paclitaxel prodrugs. Pg Txl, tang weijie, May 26, 1999: CN97194360

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm ...


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Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel prodrugs. Cell Therapeutics, Foley And Lardner, December 21, 2006: US20060287220-A1

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune d ...