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Doherty James B, Dorn Conrad P, Witzel Bruce E, Allison Debra L, Shen Tsung Ying, Finke Paul E: Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents.. Merck & Co, January 5, 1983: EP0068460-A1 (3 worldwide citation)

Compounds having the structural formula: are disclosed wherein there are 0-4 R groups and R is e.g. hydrogen, lower alkyl, halo-loweralkyl, hydroxy, lower alkoxy, halo, lower alkylthio or lower alkylsulfinyl; R is e.g. hydrogen or lower alkyl; Z is (a) -(CH2)0-n, n being 0-10; (b) -CO(CH2)1-n; (c) - ...


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James B Doherty, Conrad P Dorn, Bruce E Witzel, Debra L Allison, Tsung Ying Shen: Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents. Merck & Co, Theresa Y Cheng, Mario A Monaco, April 3, 1984: US04440779 (2 worldwide citation)

Tricyclic derivatives of substituted pyrrole acids, e.g., substituted 4,10-dihydro-10-oxo-1H-[1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to hav ...


3
Witzel Bruce E, Dorn Conrad P, Doherty James B, Shen Tsung Ying, Allison Debra L, Finke Paul E: Derives tricycliques dacides pyrrole-carboxyliques substitues, analgesiques et anti-inflammatoires, Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents. Merck &Amp Co, GOUDREAU GAGE DUBUC, April 23, 1985: CA1185971

ABSTRACT OF THE INVENTION Tricyclic derivatives of substituted pyrroleacids, e.g., substituted 4,10-dihydro-10-oxo-1H-[1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the5-thia analogs thereof have been prepared viahydrolysis of a precursor or decarboxylation of aprecursor-diacid. These tricyclic comp ...