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Linda Griffith Cima, Anthony Atala, Charles A Vacanti, Keith T Paige: Tissue formation by injecting a cell-polymeric solution that gels in vivo. Massachusetts Institute of Technology, Arnall Golden & Gregory, January 20, 1998: US05709854 (221 worldwide citation)

A cell-polymeric solution is injected into an animal where the polymer crosslinks to form a polymeric hydrogel containing dispersed cells and the cells form new tissue in the animal. The polymer is biodegradable and is a natural polymer such as alginate or a synthetic polymer. The cells are chondroc ...


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Linda Griffith Cima, Anthony Atala, Charles A Vacanti, Keith T Paige: Tissue formation by injecting a cell-polymeric solution that gels in vivo. Massachusetts Institute of Technology, Children&apos s Medical Center Corporation, Choate Hall & Stewart, May 4, 2004: US06730298 (27 worldwide citation)

Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is similar in composition and histol ...