1
Eric First, M.D.
FIRST ERIC B: Method and composition to improve absorption of therapeutic agents. BAYER HEALTHCARE, Bullitt Richard S, November 18, 2010: WO/2010/132095 (2 worldwide citation)

A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the c ...


2
Eric First, M.D.
Eric R First, Ashish B Patel, Guido Schmitz, Stephanie Petaway Hickson, Hung Huar Tong: Method and composition to improve absorption of therapeutic agents. Richard S Bullitt, Bayer HealthCare, November 11, 2010: US20100286100-A1

A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the c ...


3
Andreas G Weichert
Jan Robert Schwark, Joachim Brendel, Heinz Werner Kleemann, Hans Jochen Lang, Andreas Weichert, Udo Albus, Wolfgang Scholz: Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, March 16, 1999: US05883133 (5 worldwide citation)

Compounds of the formula I ##STR1## are described in which at least one of the substituents R(1), R(2), R(3), R(4) and R(5) is a nitrogen-containing heterocyclic radical. They are outstanding cardiovascular therapeutic agents. They are obtained by reaction of a compound II ##STR2## with guanidine.


4
Lawrence L Kunz, Richard A Klein, John M Reno, David J Grainger, James C Metcalfe, Peter L Weissberg, Peter G Anderson: Therapeutic inhibitor of vascular smooth muscle cells. NeoRx Corporation, Schwegman Lundberg Woessner & Kluth P A, March 31, 1998: US05733925 (479 worldwide citation)

Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a ce ...


5
Ralph Weissleder, Alexei Bogdanov: Hydrogel compositions and methods of use. The General Hospital Corporation, Fish & Richardson, May 7, 1996: US05514379 (420 worldwide citation)

Biocompatible, biodegradable, hydrogels are prepared from a backbone bonded to a cross-linking agent. Suitable backbones include proteins and polysaccharides, e.g,, albumin, polymannuronic acid, or polygalacturonic acid. Suitable cross-linking agents include polyvalent derivatives of polyethylene or ...


6
James E Summerton, Dwight D Weller, Eugene P Stirchak: Alpha-morpholino ribonucleoside derivatives and polymers thereof. Anti Gene Development Group, Peter J Dehlinger, Gary R Fabian, August 10, 1993: US05235033 (405 worldwide citation)

Alpha-morpholino subunits and polymer compositions composed of alpha-morpholino subunits are disclosed. These subunits can be linked together by uncharged linkages, one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each su ...


7
David A Lee: Drug delivery device. Samuels Gauthier Stevens & Kehoe, September 5, 1989: US04863457 (386 worldwide citation)

This invention relates to a medical device and a method of using the device to deliver a continuous controlled supply of a medication to a specific internal site. Specifically, the invention comprises an inert, biodegradable implant impregnated with one or more therapeutic agents designed to provide ...


8
Maureen A Shaffer, James E Leone: Balloon catheter for delivering therapeutic agents. Cordis Corporation, Gerstman & Ellis, September 17, 1991: US05049132 (371 worldwide citation)

A balloon catheter comprises a catheter shaft which typically defines a first inflation lumen and a first, inflatable balloon mounted on the shaft in communication with the first inflation lumen. By this invention a second inflation lumen is typically provided, spaced from the first lumen and define ...


9
Mahesh V Patel, Feng Jing Chen: Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents. Lipocine, Dianne E Reed, Reed & Associates, September 25, 2001: US06294192 (363 worldwide citation)

The present invention relates to triglyceride-free pharmaceutical compositions for delivery of hydrophobic therapeutic agents. Compositions of the present invention include a hydrophobic therapeutic agent and a carrier, where the carrier is formed from a combination of a hydrophilic surfactant and a ...


10
Philip L Felgner, Raj Kumar, Channa Basava, Richard C Border, Jiin Yu Hwang Felgner: Cationic lipids for intracellular delivery of biologically active molecules. Vical, Knobbe Martens Olson & Bear, October 17, 1995: US05459127 (354 worldwide citation)

Disclosed are cationic lipids capable of facilitating transport of biologically active agents into cells, including the transfection of cells by therapeutic polynucleotides, the delivery of antiviral drugs, and the introduction of immunogenic peptides. The cationic lipids, comprising an ammonium gro ...