1
Eric B Kmiec, Howard B Gamper, Michael C Rice: Targeted chromosomal genomic alterations with modified single stranded oligonucleotides. University of Delaware, Heller Ehrman White & McAuliffe, Daniel M Becker, August 30, 2005: US06936467 (82 worldwide citation)

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base a ...


2
Eric B Kmiec, Howard B Gamper, Michael C Rice: Targeted chromosomal genomic alterations with modified single stranded oligonucleotides. University of Delaware, McCarter & English, June 5, 2007: US07226785 (77 worldwide citation)

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.


3
Eric B Kmiec, Howard B Gamper, Michael C Rice: Targeted chromosomal genomic alterations with modified single stranded oligonucleotides. University of Delaware, McCarter & English, August 21, 2007: US07258854

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base a ...


4
Kmiec Eric B, Gamper Howard B, Rice Michael C, Kim Jungsup: Targeted chromosomal genomic alterations in plants using modified single stranded oligonucleotides. Univ Delaware, April 2, 2003: EP1297122-A2

Presented are methods and compositions for targeted chromosomal genomic alterations with modified single-stranded oligonucleotides. The oligonucleotides of the invention have modified nuclease-resisant termini comprising LNA, phosphorothioate linkages or 2'-O-Me base analogues or combinations of suc ...


5
Eric B Kmiec, Howard B Gamper, Michael C Rice, Jungsup Kim: Targeted chromosomal genomic alterations in plants using modified single stranded oligonucleotides. Fish & Neave, December 25, 2003: US20030236208-A1

Presented are methods and compositions for targeted chromosomal genomic alterations with modified single-stranded oligonucleotides. The oligonucleotides of the invention have modified nuclease-resistant termini comprising LNA, phosphorothioate linkages or 2-O-Me base analogues or combinations of suc ...


6
Eric B Kmiec, Howard B Gamper, Michael C Rice: Targeted chromosomal genomic alterations with modified single stranded oligonucleotides. Daniel M Becker, c o FISH & NEAVE, January 22, 2004: US20040014057-A1

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2-O-Me base analogs.


7
Eric B Kmiec, Howard B Gamper, Michael C Rice: Targeted chromosomal genomic alterations with modified single stranded oligonucleotides. University of Delaware, Fish & Neave, November 20, 2003: US20030217377-A1

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2-0-Me base an ...


8
Eric B Kmiec, Howard B Gamper, Michael C Rice: Targeted chromosomal genomic alterations with modified single stranded oligonucleotides. Fish & Neave, March 13, 2003: US20030051270-A1

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2-O-Me base an ...


9
Kmiec Eric B, Gamper Howard B, Rice Michael C, Kim Jungsup: Targeted chromosomal genomic alterations in plants using modified single stranded oligonucleotides. University Of Delaware, Kmiec Eric B, Gamper Howard B, Rice Michael C, Kim Jungsup, sHALEY James F Jr, December 6, 2001: WO/2001/092512

Presented are methods and compositions for targeted chromosomal genomic alterations with modified single-stranded oligonucleotides. The oligonucleotides of the invention have modified nuclease-resisant termini comprising LNA, phosphorothioate linkages or 2'-O-Me base analogues or combinations of suc ...


10
Kmiec Eric B, Gamper Howard B, Rice Michael C: Targeted chromosomal genomic alterations with modified single stranded oligonucleotides. University Of Delaware, Kmiec Eric B, Gamper Howard B, Rice Michael C, sHALEY James F Jr, October 4, 2001: WO/2001/073002

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuc ...