1
Ulrike D Spohr, Michael J Malone, Nathan B Mantlo: Substituted pyrimidine compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, June 25, 2002: US06410729 (21 worldwide citation)

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ...


2
Ulrike D Spohr, Michael J Malone, Nathan B Mantlo: Substituted pyrimidine compounds and methods of use. Amgen, Richard V Person, Ron K Levy, Stuart L Wattt, August 26, 2003: US06610698 (5 worldwide citation)

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ...


3
Aleem Gangjee, Larry H Matherly: Substituted pyrimidine compounds and methods of use and manufacture. Duquesne University of the Holy Ghost, Eckert Seamans Cherin & Mellott, Carol A Marmo, May 16, 2017: US09650384

This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts, hydrates, or solvates thereof, that are useful in treating a patient having a disease or cancer. The comp ...


4
Ulrike D Spohr, Michael J Malone, Nathan B Mantlo: Substituted pyrimidine compounds and methods of use. Amgen, Amgen Incorporated, April 10, 2003: US20030069425-A1

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-, IL-1, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable ...


5
Substituted Pyrimidine Compounds and Methods of Use and Manufacture. February 11, 2016: US20160039830-A1

This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts, hydrates, or solvates thereof, that are useful in treating a patient having a disease or cancer. The comp ...


6
SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE. DUQUESNE UNIVERSITY OF THE HOLY SPIRIT, WAYNE STATE UNIVERSITY, May 9, 2019: US20190135816-A1

This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts, hydrates, or solvates thereof, that are useful in treating a patient having a disease or cancer. The comp ...