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Lu Tianbao, Milkiewicz Karen L, Raboisson Pierre, Cummings Maxwell David, Calvo Raul R, Parks Daniel J, Lafrance Louis V Iii, Marugan, Sanchez Juan Jose, Gushue Joan, Leonard Kristi: Substituted 1,4-diazepines and uses thereof. Ortho Mcneil Pharmaceuticals, Lu Tianbao, Milkiewicz Karen L, Raboisson Pierre, Cummings Maxwell David, Calvo Raul R, Parks Daniel J, Lafrance Louis V Iii, Marugan, Sanchez Juan Jose, Gushue Joan, Leonard Kristi, JOHNSON Philip S, November 11, 2004: WO/2004/096134 (11 worldwide citation)

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I as defined herein, with R 1 to R 8 and X as defined herein or a solvate, hydrate or pharmaceutically acceptable salt th ...


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Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V Lafrance III, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Ortho McNeil Pharmaceutical, Laura Donnelly, October 3, 2006: US07115598 (2 worldwide citation)

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined ...


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Lu Tianbao, Milkiewicz Karen L, Raboisson Pierre, Cummings Maxwell David, Calvo Raul R, Parks Daniel J, Lafrance Louis V Iii, Marugan Sanchez Juan Jose, Gushue Joan, Leonard Kristi: Substituted 1,4-diazepines and uses thereof. Ortho Mcneil Pharmaceuticals I, January 25, 2006: EP1617807-A2

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I as defined herein, with R to R and X as defined herein or a solvate, hydrate or pharmaceutically acceptable salt thereo ...


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Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V Lafrance, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Philip S Johnson, Johnson & Johnson, November 4, 2004: US20040220179-A1

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: 1 or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are define ...


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Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V LaFrance, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Philip S Johnson, Johnson & Johnson, October 19, 2006: US20060235007-A1

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined h ...


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Lu Tianbao, Milkiewicz Karen L, Raboisson Pierre, Cummings Maxwell David, Calvo Raul R, Parks Daniel J, Lafrance Louis V Iii, Marugan Sanchez Juan Jose, Gushue Joan, Leonard Kristi: Substituted 1,4-diazepines and uses thereof. Johnson &Amp Johnson, duan xiaoling, July 26, 2006: CN200480017252

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I as defined herein, with R to R and X as defined herein or a solvate, hydrate or pharmaceutically acceptable salt thereo ...


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Lu Tianbao, Milkiewicz Karen L, Raboisson Pierre, Cummings Maxwell David, Calvo Raul R, Parks Daniel J, Lafrance Louis V Iii, Marugan Sanchez Juan Jose, Gushue Joan, Leonard Kristi: Substituted 1,4-diazepines and uses thereof. Ortho Mcneil Pharmaceutical, January 23, 2006: KR1020057020301

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I as defined herein, with R 1 to R 8 and X as defined herein or a solvate, hydrate or pharmaceutically acceptable salt th ...


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