1
Jan Vandenberk, Ludo Kennis, Marcel Van der Aa, Albert Van Heertum: Piperidinylalkyl quinazoline compounds, composition and method of use. Janssen Pharmaceutica, Geoffrey G Dellenbaugh, June 15, 1982: US04335127 (73 worldwide citation)

Novel quinazoline derivatives, comprising in the heterocyclic part of their quinazoline nucleus at least one carbonyl or thiocarbonyl group and a particularly substituted piperidinyl-alkyl side chain, said compounds being potent serotonin-antagonists.


2
Edward E Beedle, David W Robertson, David T Wong: Serotonin antagonists. Eli Lilly and Company, Robert A Conrad, Leroy Whitaker, May 7, 1991: US05013761 (60 worldwide citation)

This invention provides a method of selectively antagonizing the 5-HT.sub.1A receptor in mammals by administering aryloxypropanolamines. Novel aryloxypropanolamines are also claimed.


3
Azria Moise, Buchheit Karl Heinz, Dixon Keith Arnold, Engel Gunther, Giger Rudolf Karl Andreas: Therapeutic use of serotonin antagonists. Sandoz, February 17, 1988: GB2193633-A (48 worldwide citation)

Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufacture of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigilance, for the treatment of rhinitis or serotonin-induced disorde ...


4
Richardson Brian P, Giger Rudolf K A, Engel Gunter, Furler Roland: Carbocyclic and heterocyclic carbonylmethylene- and carbonylmethylpiperidines and - pyrrolidines as serotonin antagonists. Sandoz, July 9, 1986: GB2169292-A (38 worldwide citation)

L'INVENTION A POUR OBJET LES COMPOSES CONTENANT UN SYSTEME CARBOCYCLIQUE OU HETEROCYCLIQUE LIE PAR L'INTERMEDIAIRE D'UN GROUPE CARBONYL-METHYLENE OU CARBONYL-METHYLE A UN CYCLE PIPERIDINE OU PYRROLIDINE, LE RESTE CARBONYLE ETANT FIXE SUR LE SYSTEME CARBOCYCLIQUE OU HETEROCYCLIQUE ET LEDIT CYCLE PIPE ...


5
Wolfgang Muller, Thomas Stratz: Use of serotonin antagonists for treating fibromyalgia. Novartis, Joseph J Borovian, June 30, 1998: US05773436 (38 worldwide citation)

The invention is directed to the use of 5HT.sub.3 antagonists of formula I ##STR1## wherein the substituents are as defined herein.


6
Roman Rozencwaig: Method of medical treatment with serotonin antagonists. Foley & Lardner Schwartz Jeffery Schwaab Mack Blumenthal & Evans, September 13, 1988: US04771056 (26 worldwide citation)

Treatment of patients suffering from cancer, acquired immuno deficiency syndrome, multiple sclerosis, by administration of a serotonin antagonist, the administration taking place once a day during the evening, preferably after sunset.


7
Jeffery B Press, Ronald K Russell: Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents. Ortho Pharmaceutical Corporation, Benjamin F Lambert, May 30, 1989: US04835157 (24 worldwide citation)

Novel thienopyrimidine-2,4-dione piperidine derivatives and novel furo[3,4-d]pyrimidine-2,4-dione piperidine derivatives are described. The novel piperidine derivatives are selective serotonin antagonists and alpha adrenergic blocking agents with cardiovascular, gastrointestinal and central nervous ...


8
Rozencwaig Roman: Use of serotonin antagonists, particularly cyproheptadine, in the treatment of cancer, alzheimers disease, aids and multiple sclerosis.. Rozencwaig Roman, March 18, 1987: EP0214557-A2 (24 worldwide citation)

The present invention relates to the use of serotonin antagonists and particularly cyproheptadine for treatment of patients suffering from cancer, acquired immuno deficiency syndrome, multiple sclerosis and Alzheimer's disease by administration of doses of about 0.5 to 4 mg of said serotonin antagon ...


9
Azria Moise, Buchheit Karl Heinz, Dixon Keith Arnold, Engel Gunther, Giger Rudolf Karl Andreas: Therapeutic use of serotonin antagonists. Sandoz, November 14, 1990: GB2231265-A (23 worldwide citation)

Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufacture of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigilance, for the treatment of rhinitis or serotonin-induced disorde ...


10
Roman Rozencwaig: Method of medical treatment with serotonin antagonists. Schwartz Jeffery Schwaab Mack Blumenthal & Evans, April 28, 1987: US04661500 (23 worldwide citation)

Treatment of patients suffering from acquired immuno deficiency syndrome, multiple sclerosis, Alzheimer's disease, by administration of a serotonin antagonist, said administration taking place once a day during the evening.



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