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Kempf Dale J, Plattner Jacob J, Norbeck Daniel W, Baker William R, Fung Anthony K L, Boyd Steven A, Erickson John W, Crowley Steven R: Retroviral protease inhibitors.. Abbott Lab, November 23, 1989: EP0342541-A2 (159 worldwide citation)

A retroviral protease inhibiting compound of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof.


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Kempf Dale J, Codacovi Lynn M, Norbeck Daniel W, Plattner Jacob J, Sham Hing L, Wittenberger Steven J, Zhao Chen: Retroviral protease inhibiting compounds.. Abbott Lab, May 27, 1992: EP0486948-A2 (116 worldwide citation)

A retroviral protease inhibiting compound of the formula A -X- B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhi ...


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Dale J Kempf, Daniel W Norbeck, Lynn M Codacovi, Jacob J Plattner, Hing L Sham, Chen Zhao: Retroviral protease inhibiting compounds. Abbott Laboratories, Steven R Crowley, October 11, 1994: US05354866 (97 worldwide citation)

A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhi ...


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Patrick Yuk Sun Lam, Prabhakar Kondaji Jadhav, Charles Joseph Eyermann, Carl Nicholas Hodge, George Vincent De Lucca, James David Rodgers: Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors. The DuPont Merck Pharmaceutical Company, Blair Q Ferguson, September 22, 1998: US05811422 (58 worldwide citation)

This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the c ...


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Budt Karl Heinz Dr, Stowasser Bernd Dr, Ruppert Dieter Dr, Meichsner Christoph Dr, Paessens Arnold Dr, Hansen Jutta Dr, Knolle Jochen Dr: Retroviral protease inhibitors.. Hoechst, May 29, 1991: EP0428849-A2 (51 worldwide citation)

The present invention relates to a compound of the formula I in which A, Y, R, R, R, R, R, l, m and the corresponding radicals with are defined as indicated in the description, a process for the preparation thereof, and the use thereof for inhibiting retroviral proteases.


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Dale J Kempf, Daniel W Norbeck, Lynn M Codacovi, Hing L Sham, Steven J Wittenberger: Retroviral protease inhibiting compounds. Abbott Laboraotries, Steven R Crowley, July 15, 1997: US05648497 (45 worldwide citation)

A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhi ...


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Michael L Vazquez, Richard A Mueller, John J Talley, Daniel Getman, Gary A DeCrescenzo, John N Freskos: .alpha.-and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors. G D Searle & Co, Banner & Witcoff, December 1, 1998: US05843946 (30 worldwide citation)

.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.


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