1
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Covenentech, Viksnins Harris & Padys PLLP, November 22, 2011: US08063050 (25 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


2
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genertech, Viksnins Harris & Padys PLLP, August 23, 2011: US08003651 (22 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


3
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array Biopharma, Genentech, Viksnins Harris & Padys PLLP, October 7, 2014: US08853199 (7 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


4
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genentech, Viksnins Harris & Padys PLLP, September 30, 2014: US08846681 (7 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


5
Anna L Banka, James F Blake, Josef R Bencsik, Kin Chiu Fong, Martin F Hentemann, Douglas M Sammond, Ian S Mitchell, Rui Xu, Eli M Wallace, Tony Tang: Pyrimidyl cyclopentanes as Akt protein kinase inhibitors. Array Biopharma, Viksnins Harris & Padys PLLP, December 4, 2012: US08324221 (5 worldwide citation)

The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitor ...


6
Josef R Bencsik, James F Blake, Nicholas C Kallan, Ian S Mitchell, Keith L Spencer, Dengming Xiao, Rui Xu, Christine Chabot, Jun Liang, Brian S Safina: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genentech, Viksnins Harris & Padys PLLP, February 19, 2013: US08377937 (4 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


7
Banka Anna, Bencsik Josef R, Blake James F, Fong Kin Chiu, Hentemann Martin F, Mitchell Ian S, Sammond Douglas Mccord, Tang Tony P, Wallace Eli M, Xu Rui: Pyrimidyl cyclopentanes as akt protein kinase inhibitors. Array Biopharma, Banka Anna, Bencsik Josef R, Blake James F, Fong Kin Chiu, Hentemann Martin F, Mitchell Ian S, Sammond Douglas Mccord, Tang Tony P, Wallace Eli M, Xu Rui, HARRIS Robert J, July 16, 2009: WO/2009/089454 (3 worldwide citation)

The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitor ...


8
Bencsik Josef, Blake James F, Graham James M, Hentemann Martin F, Kallan Nicholas C, Mitchell Ian S, Schlacter Stephen T, Spencer Keith L, Xiao Dengming, Xu Rui, Welch Mike, Liang Jun, Safina Brian S: Pyrimidyl cyclopentanes as akt protein kinase inhibitors. Array Biopharma, Genentech, Bencsik Josef, Blake James F, Graham James M, Hentemann Martin F, Kallan Nicholas C, Mitchell Ian S, Schlacter Stephen T, Spencer Keith L, Xiao Dengming, Xu Rui, Welch Mike, Liang Jun, Safina Brian S, VIKSNINS Ann S, January 8, 2009: WO/2009/006567 (3 worldwide citation)

The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and fo ...


9
Josef Bencsik, James F Blake, James M Graham, Martin F Hentemann, Nicholas C Kallan, Ian S Mitchell, Stephen T Schlachter, Keith L Spencer, Dengming Xiao, Rui Xu, Mike Welch, Jun Liang, Brian S Safina: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array Biopharma, Genentech, Viksnins Harris & Padys PLLP, December 31, 2013: US08618097 (2 worldwide citation)

The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and fo ...


10
Josef R Bencsik, James F Blake, Nicholas C Kallan, Ian S Mitchell, Keith Lee Spencer, Dengming Xiao, Rui Xu, Christine Chabot, Steven Do, Jun Liang, Brian Safina, Birong Zhang: Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors. Array Biopharma, Genentech, Viksnins Harris & Padys PLLP, September 16, 2014: US08835434 (2 worldwide citation)

The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.



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