1
David H Gelfand, Susanne Stoffel, Frances C Lawyer, Randall K Saiki: Purified thermostable enzyme. Cetus Corporation, Janet E Hasak, Kevin R Kaster, Albert P Halluin, December 26, 1989: US04889818 (426 worldwide citation)

A purified thermostable enzyme is obtained that has unique characteristics. Preferably the enzyme is isolated from the Thermus aquaticus species and has a molecular weight of about 86,000-90,000 daltons. The thermostable enzyme may be native or recombinant and may be used in a temperature-cycling ch ...


2
David H Gelfand, Susanne Stoffel, Frances C Lawyer, Randall K Saiki: Purified thermostable enzyme. Cetus Corporation, Lisabeth F Murphy, Kevin R Kaster, January 7, 1992: US05079352 (183 worldwide citation)

Recombinant DNA vectors that encode a thermostable DNA polymerase are useful in the recombinant production of thermostable DNA polymerase. The recombinant thermostable polymerase is preferred for use in the production of DNA in a polymerase chain reaction. Especially useful vectors encode the .about ...


3
Erlich Henry Anthony, Horn Glenn, Saiki Randall Keichi, Stoffel Susanne, Mullis Kary Banks, Lawyer Frances Cook, Gelfand David Harrow: Purified thermostable enzyme and process for amplifying, detecting, and/or cloning nucleic acid sequences using said enzyme.. Cetus, March 2, 1988: EP0258017-A2 (150 worldwide citation)

A purified thermostable enzyme is obtained that has unique characteristics. Preferably the enzyme is isolated from the Thermus aquaticus species and has a molecular weight of about 86,000-90,000 daltons. The thermostable enzyme may be native or recombinant and may be used in a temperature-cycling ch ...


4
David H Gelfand, Frances C Lawyer: DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima. Hoffmann La Roche, George M Gould, Dennis P Tramaloni, Stacey R Sias, December 20, 1994: US05374553 (97 worldwide citation)

A purified thermostable enzyme is derived from the eubacterium Thermotoga maritima. The enzyme has a molecular weight of about 97 kilodaltons and DNA polymerase I activity. The enzyme can be produced from native or recombinant host cells and can be used with primers and nucleoside triphosphates in a ...


5
Richard D Abramson, David H Gelfand, I Lawrence Greenfield: DNA encoding thermostable nucleic acid polymerase enzyme from thermus species Z05. Roche Molecular Systems, George W Johnston, Patricia S Rocha Tramaloni, Stacey R Sias, October 7, 1997: US05674738 (78 worldwide citation)

A purified thermostable enzyme is derived from the eubacterium Thermus species Z05. The enzyme has DNA polymerase, activity reverse transcriptase activity, and optionally 5'.fwdarw.3' exonuclease activity. The enzyme can be native or recombinant, and may be used with primers and nucleoside triphosph ...


6
Richard D Abramson, David H Gelfand, I Lawrence Greenfield: Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05. Hoffmann La Roche, George M Gould, Dennis P Tramaloni, Stacey R Sias, October 3, 1995: US05455170 (60 worldwide citation)

A purified thermostable enzyme is derived from the eubacterium Thermus species Z05. The enzyme has DNA polymerase, activity reverse transcriptase activity, and optionally 5'.fwdarw.3' exonuclease activity. The enzyme can be native or recombinant, and may be used with primers and nucleoside triphosph ...


7
David H Gelfand, Frances C Lawyer, Susanne Stoffel: Purified thermostable nucleic acid polymerase enzyme from Thermotoga maritima. Hoffmann La Roche, George W Johnston, Patricia S Rocha Tramaloni, Stacey R Sias, April 29, 1997: US05624833 (53 worldwide citation)

A purified thermostable enzyme is derived from the eubacterium Thermotoga maritima. The enzyme has a molecular weight as determined by gel electrophoresis of about 97 kilodaltons and DNA polymerase I activity. The enzyme can be produced from native or recombinant host cells and can be used with prim ...


8
David H Gelfand, Susanne Stoffel: Purified thermostable enzyme. Hoffmann La Roche, George M Gould, Dennis P Tramaloni, Stacey R Sias, October 4, 1994: US05352600 (52 worldwide citation)

A purified thermostable enzyme is obtained that has unique characteristics. Preferably the enzyme is isolated from the Thermus aquaticus species and has a molecular weight of about 86,000-95,000 daltons. The thermostable enzyme may be native or recombinant and may be used in a temperature-cycling ch ...


9
David H Gelfand, Frances C Lawyer, Susanne Stoffel: Mutated thermostable nucleic acid polymerase enzyme from thermotoga maritima. Hoffmann La Roche, George M Gould, Dennis P Tramaloni, Stacey R Sias, May 30, 1995: US05420029 (49 worldwide citation)

A purified thermostable enzyme is derived from the eubacterium Thermotoga maritima. The enzyme has a molecular weight as determined by gel electrophoresis of about 97 kilodaltons and DNA polymerase I activity. The enzyme can be produced from native or recombinant host cells and can be used with prim ...


10
David E Lam, Eric J Mathur: Endoglucanases. Diversa Corporation, Fish & Richardson P C, August 4, 1998: US05789228 (47 worldwide citation)

A purified thermostable enzyme is derived from the archael bacterium AEPII1a. The enzyme has a molecular weight of about 60.9 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of cellulose where desired.