1
Mertelsmann Roland, Welte Karl, Venuta Salvatore: Purification of interleukin 2.. Sloan Kettering Inst Cancer, October 26, 1983: EP0092163-A2 (35 worldwide citation)

Interleukin 2 (IL 2; T-cell growth factor), produced with and without costimulation by Burkitt's lymphoma line Daudi, is purified approximately 37,000-fold to apparent homogeneity from lymphocyte-conditioned medium by (NH4)2SO4- precipitation, ion-exchange chromatography, gel filtration and hydropho ...


2
Pascal Bailon, John E Smart, David V Weber: Purification of chimeric proteins containing an IL-2 moiety by receptor-affinity chromatography. Hoffmann La Roche, George M Gould, William H Epstein, Patricia S Rocha, September 22, 1992: US05149788 (2 worldwide citation)

Methods are provided for the purification of interleukin-2 (IL-2) and chimeric proteins containing an IL-2 moiety from a wide variety of sources, including synthetic mixtures, cell culture conditioned medium and mammalian and bacterial recombinant expression systems. The methods of the invention emp ...


3
Pascal Bailon, John E Smart, David V Weber: Purification of interleukin-2 by receptor-affinity chromatography. Hoffmann La Roche, George M Gould, William H Epstein, Patricia S Rocha, November 10, 1992: US05162503 (2 worldwide citation)

Methods are provided for the purification of interleukin-2 (IL-2) from a wide variety of sources, including synthetic mixtures, culture medium conditioned by natural IL-2 producing cells, and mammalian and bacterial recombinant IL-2 expression systems. The methods of the invention employ IL-2 recept ...


4
Bailon Pascal, Smart John Edward, Weber David Vincent: Purification of il-2 by recepter-affinity chromatography.. Hoffmann La Roche, November 23, 1988: EP0291988-A2

IL-2 receptor affinity adsorbents which contain soluble IL-2 receptor molecules which are immobilised on a solid carrier are prepared as described and are used in methods for the purification of interleukin-2 (IL-2) from various sources, e.g. from synthetic mixtures, from culture media which are con ...


5
PHARMACEUTICAL COMPOSITIONS OF IL-2. ILTOO PHARMA, October 25, 2018: US20180303754-A1

The invention relates to a liquid pharmaceutical composition of I1-2 and its use in the treatment of auto-immune and inflammatory disorders. Methods for preparing said composition and delivery devices filled with said composition are also described.