1
Gautam Mitra: Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer. Miles Laboratories, Lester E Johnson, January 29, 1985: US04496689 (450 worldwide citation)

There is disclosed a process for producing a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex useful for pulmonary emphysema therapy, a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex produced by the process, a composition thereof in a ...


2
Higuchi Naoki, Saitoh Masayuki, Shibata Hiroshi: Proteinase inhibitor.. Suntory, October 24, 1990: EP0393457-A1 (170 worldwide citation)

A proteinase inhibitory compound represented by the following general formula (1): wherein R1 represents a straight-chain or branched acyl group having 2 to 10 carbon atoms, a branched-, cyclic- or polycyclic-alkyloxycarbonyl group having 4 to 15 carbon atoms, a substituted- or unsubstituted-benzylo ...


3
Andrew Hepher, Howard J Atkinson: Nematode control with proteinase inhibitors. Nickerson Biocem, Hale and Dorr, February 27, 1996: US05494813 (40 worldwide citation)

The present invention is directed to methods of controlling plant parasitic nematodes using proteinase inhibitors, particularly those in the Bowman-Birk family which includes cowpea trypsin inhibitors. Nematode resistance can be conferred on plants by transforming them to express a gene or other DNA ...


4
Okamoto Shosuke, Okada Yoshio, Okunomiya Akiko, Naito Taketoshi Showa Denko K, Yamada Morihiko Showa Denko K, Kimura Yoshio Showa Denko K K, Katsuura Yasuhiro Showa Denko, Suzuki Hiroshi Showa Denko K K, Ohno Norio Showa Denko K K, Seki Yumi Showa Denko K K: Lysin derivative and proteinase inhibitor.. Okamoto Shosuke, Showa Denko, June 4, 1986: EP0183271-A2 (35 worldwide citation)

A lysine derivative having the general formula: A-Y-Lys-B (L-form) (A) wherein A represents wherein X and X min independently represent hydrogen, halogen, alkyl, cycloalkyl, alkoxy, aryloxy, dialkylamino, alkylcarbonyl amino, arylcarbonyl amino, and n1 is an integer of 3 to 6, n2 is an integer of 1 ...


5
Wytold R Lebing, Sharon X Chen: Purification of .alpha.-1 proteinase inhibitor using novel chromatographic separation conditions. Bayer Corporation, James A Giblin, March 11, 1997: US05610285 (32 worldwide citation)

Cation chromatography with solutions at pH less than 6.0 and low ionic strength can be utilized to purify human .alpha.-1 proteinase inhibitor (.alpha.-1 PI) from biological fluids including plasma and plasma fractions. The cation chromatography takes advantage of the fact that active .alpha.-1 PI d ...


6
Naoki Higuchi, Masayuki Saitoh, Norio Iwasawa, Motoo Sumida, Hiroshi Shibata: Proteinase inhibitor. Suntory, Cushman Darby & Cushman, January 14, 1992: US05081284 (32 worldwide citation)

A novel N-substituted peptidyl compound represented by the general formula (1): ##STR1## where R.sub.1 is a straight-chained or branched acyl group having 2-10 carbon atoms, a branched, cyclic or partly branched cyclic alkyloxycarbonyl group having 4-15 carbon atoms, a substituted or unsubstituted b ...


7
Christopher Davies, Dadong Chen, Steve Roczniak: Protein having proteinase inhibitor activity. Michael J Beck, January 30, 2001: US06180607 (28 worldwide citation)

BTL.010 is a novel human serine proteinase inhibitor of the Kunitz family that exhibits greater potency towards neutral serine proteinases, particularly leukocyte elastase-, and proteinase 3, than towards trypsin-like proteinases. BTL.010, or variants thereof, may be employed as therapeutics in dise ...


8
Hans Lilja, Ulf Hakan Stenman: Assay of free and complexed prostate-specific antigen. March 26, 1996: US05501983 (27 worldwide citation)

According to the method of the invention, immunoassays are applied to measure free PSA as well as a proteinase inhibitor complex. Free PSA and PSA complex are according to the invention measured by a non-competitive immunoassay employing at least two different antibodies. The invention is further ch ...


9
Michael A Shearer, Pamela K Sasagawa, Ronald H Hein: Method of preparing alpha-1-proteinase inhibitor and antithrombin III. Miles Laboratories, Pamela A Simonton, Lester E Johnson, April 7, 1987: US04656254 (27 worldwide citation)

There is disclosed an improved method for separating one of alpha-1-proteinase inhibitor (also known as alpha-1 antitrypsin) and antithrombin-III from an aqueous solution of plasma proteins containing the same, such as from Cohn Fraction IV-1, Cohn Fraction IV, reworks of Cohn Fraction IV and IV-1, ...


10
James Travis, Jan S Potempa, Philip J Barr, Nadine Pavloff: Porphyromonas gingivalis arginine-specific proteinase. University of Georgia Research Foundation, Greenlee and Winner, June 4, 1996: US05523390 (27 worldwide citation)

Provide herein is a substantially pure gingipain-1 preparation, gingipain-1 being characterized as having an apparent molecular mass of 50 kDa as estimated by sodium dodecyl sulfate polyacrylamide gel electrophoresis and an apparent molecular mass of 44 kDa as estimated by gel filtration chromatogra ...