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SINGH JUSWINDER: Protein kinase conjugates and inhibitors. AVILA THERAPEUTICS, Underwood Robert H, March 24, 2011: WO/2011/034907 (50 worldwide citation)

The invention relates to protein conjugates that contain a protein kinase containgn a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention a ...


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Juswinder Singh, Russell Colyn Petter, Deqiang Niu, Lixin Qiao, Arthur Kluge, Roy Lobb, Shomir Ghosh, Zhendong Zhu: Protein kinase conjugates and inhibitors. Celgene Avilomics Research, Jones Day, January 31, 2017: US09556426

The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention ...


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Juswinder Singh, Russell Colyn Petter, Deqiang Niu, Lixin Qiao, Arthur Kluge, Roy Lobb, Shomir Ghosh, Zhendong Zhu: Protein Kinase Conjugates and Inhibitors. Avila Therapeutics, May 19, 2011: US20110117073-A1

The invention relates to protein conjugates that contain a protein kinase containg a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention al ...


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Singh Juswinder, Petter Russell Colyn, Niu Deqiang, Qiao Lixin, Kluge Arthur, Lobb Roy, Ghosh Shomir, Zhu Zhendong: Protein kinase conjugates and inhibitors. Avila Therapeutics, wang gaoran zhou jianqiu, October 3, 2012: CN201080050753

The invention relates to protein conjugates that contain a protein kinase containgn a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention a ...