1
Timothy D Heath, Pang Shek, Demetrios Papahadjopoulos: Production of immunogens by antigen conjugation to liposomes. The Regents of the University of California, Bertram I Rowland, January 21, 1986: US04565696 (45 worldwide citation)

Enhanced immunogenicity is achieved by covalently linking immunogens to liposomes and injecting the membrane-bound-proteins into an appropriate vertebrate host. Methods and compositions are provided for producing antibodies.


2
Papahadjopoulos Demetrios, Heath Timothy D, Shek Pang: Production dimmunogenes par conjugaison dun antigene a des liposomes, Production of immunogens by antigen conjugation to liposomes. Her Majesty The Queen In Right Of Canada Represented By The Ministe, ANDERSON J WAYNE, November 1, 1988: CA1243946

ABSTRACT The invention disclosed relates to antigen/liposomeconjugates, wherein the antigen is covalently bound to lipidmolecules in the surface membrane of liposome vesicles, andwherein at least about 25 g of antigen is provided per mole oflipid. Enhanced immunogenicity is achieved by injecting the ...