1
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (97 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


2
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, August 11, 1998: US05792756 (76 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


3
Starrett John Edward Jr, Mansuri Muzammil M, Martin John C, Tortolani David R, Bronson Joanne J: Prodrugs of phosphonates.. Squibb Bristol Myers Co, April 22, 1992: EP0481214-A1 (72 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


4
Constantine G Boojamra, Kuei Ying Lin, Richard L Mackman, David Y Markevitch, Oleg V Petrakovsky, Adrian S Ray, Lijun Zhang: Phosphonate analogs of HIV inhibitor compounds. Gilead Sciences, February 28, 2017: US09579332

The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Starrett John Edward Jr, Mansuri Muzammil M, Martin John C, Tortolani David R, Bronson Joanne J: Promedicaments a base de phosphonates, Prodrugs of phosphonates. Bristol Myers Squibb Company, Institute Of Organic Chemistry And Biochemistry Of The Academy Of, Rega Stichting Vzw, CASSAN MACLEAN, March 25, 2003: CA2051239

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


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ANTIVIRAL COMPOUNDS. March 30, 2017: US20170088576-A1

The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.



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