1
Hubert Koster, Nanda D Sinha: Process for the preparation of oligonucleotides. Biosyntech, Hamilton Brook Smith and Reynolds, February 16, 1988: US04725677 (312 worldwide citation)

The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound nucleoside-nucl ...


2
Hubert Koster: Process for the preparation of oligonucleotides in solution. Hamilton Brook Smith & Reynolds, March 30, 1993: US05198540 (35 worldwide citation)

Process for the preparation of oligonucleotides by successive linking of individual or several nucleoside and/or nucleotide units in a homogeneous phase system using a bi-, tri- or tetra-functional carrier molecule of the general formula Sp(X).sub.n, wherein X is a reactive group which is compatible ...


3
Yogesh S Sanghvi, Quanlai Song: Process for the preparation of oligonucleotides. ISIS Pharmaceuticals, Woodcock Washburn, October 26, 2004: US06809195 (8 worldwide citation)

The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a single step. The methods result in increased efficiency and are especially amenable to the large scale sy ...


4
Lebleu Bernard Residence Le Ja, Bayard Bernard: Oligonucleotides, process for their preparation and their uses as mediators in the enhancement of the effects of interferons.. Centre Nat Rech Scient, January 29, 1986: EP0169775-A1 (7 worldwide citation)

For the Contracting States : BE, CH, DE, GB, IT, LI, LU, NL, SE 1. Oligonucleotides of general formula (I) : see diagramm : EP0169775,P99,F1 in which : - Y and T are identical or different and represent O, S, Se, NH ; - Z and W are identical or different and represent O, S, NH ; - one at least of th ...


5
Paul McCormac: Process for the preparation of oligonucleotides. Avecia Biotechnology, Morgan Lewis Bockius, December 22, 2009: US07635772 (5 worldwide citation)

A process for the synthesis of an oligonucleotide is provided in which an oligonucleotide is assembled on a swellable solid support using the phosphoramidite approach in the presence of an activator, wherein the activator is not tetrazole or a substituted tetrazole. Preferred activators are pyridini ...


6
Wolfgang K D Brill: TTTr as protective group in nucleotide synthesis. Ciba Geigy Corporation, Marla J Mathias, Gregory D Ferraro, George R Dohmann, June 17, 1997: US05639867 (5 worldwide citation)

The invention relates to nucleosides, nucleotides and oligonucleotides carrying in their basic structure a primary hydroxyl group protected by tris-4,4',4"-tert-butylphenylmethyl, to processes for the preparation of said nucleosides and nucleotides, to a process for the preparation of oligonucleotid ...


7
Waldmann Herbert Prof Dr, Reidel Armin, Heuser Axel, Muehlegger Klaus, Von Der Eltz Herbert Dr, Birkner Christian Dr: Use of nucleosides and nucleoside derivatives with enzymatically cleavable protecting groupes in the synthesis of oligonucleotiden.. Boehringer Mannheim, April 26, 1995: EP0649855-A1 (2 worldwide citation)

Process for the preparation of oligonucleotides of the formula II in which the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deazaadenine and 7-deazaguanine carry N-phenylacetyl groups, are used for oligonucleotide synthesis, wherein in a first step a starting nucleotide is bonde ...


8
Hubert Koster, Nanda D Sinha: Process for the preparation of oligonucleotides. Biosyntech, Hamilton Brook Smith & Reynolds, September 15, 1992: USRE034069

The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound nucleoside-nucl ...


9

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Koster Hubert, Sinha Nanda D: Preparation doligonucleotides, Process for the preparation of oligonucleotides. Proligo, MARKS & CLERK, March 15, 1988: CA1234060

Abstract of the disclosure The invention relates to a process for the prepa-ration of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the c ...