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David J Grainger, James C Metcalfe, Lawrence L Kunz, Robert W Schroff, Peter L Weissberg: Prevention and treatment of cardiovascular pathologies. NeoRx Corporation, Schwegman Lundberg Woessner & Kluth P A, June 23, 1998: US05770609 (99 worldwide citation)

A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): ##STR1## wherein Z is C.dbd.O or a covalent bond; Y is H or O(C.sub.1 -C.sub.4)alkyl, R.sup.1 and R.sup.2 are individually (C.sub.1 -C.sub.4)alkyl or together with N are a saturated heteroc ...


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Grainger David J, Metcalfe James C, Kunz Lawrence L, Kemp Paul R, Schroff Robert W, Weissberg Peter L: Prevention and treatment of cardiovascular pathologies with tamoxifen analogues. Poniard Pharmaceuticals, October 15, 2008: EP1980246-A1

Use is provided of a compound of formula (I): wherein Z is C=O or a covalent bond; Y is H or O(C 1 -C 4 )alkyl, R 1 and R 2 are individually (C 1 -C 4 )alkyl or together with N are a saturated heterocyclic group, R 3 is ethyl or chloroethyl, R 4 is H or together with R 3 is -CH 2 -CH 2 - or -S-, R 5 ...


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Grainger David J, Metcalfe James C, Kunz Lawrence L, Kemp Paul R, Schroff Robert W, Weissberg Peter L: Prevention et traitement de pathologies cardio-vasculaires au moyen danalogues de tamoxifene, Prevention and treatment of cardiovascular pathologies with tamoxifen analogues. Neorx Corporation, Poniard Pharmaceuticals, GOUDREAU GAGE DUBUC, December 19, 1996: CA2223595

A method for treating or preventing cardiovascular pathologies by administer-ing a compound of formula (I), wherein Z is C=O or a covalent bond; Y is H or O(C1-C4)alkyl, R1 and R2 are individu-ally (C1-C4)alkyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 is ...


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David J Grainger, James C Metcalfe, Lawrence L Kunz, Robert W Schroff: Prevention and treatment of cardiovascular pathologies with tamoxifen analogues. NeoRx Corporation, Schwegman Lundberg Woessner & Kluth Pa, June 6, 2002: US20020068731-A1

A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): 1 wherein Z is CO or a covalent bond; Y is H or O(C1-C4)alkyl, R1 and R2 are individually (C1-C4)allyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 ...


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David J Grainger, James C Metcalfe, Lawrence L Kunz, Robert W Schroff: Prevention and treatment of cardiovascular pathologies with tamoxifen analogues. NeoRx Corporation, Schwegman Lundberg Woessner & Kluth Pa, June 22, 2006: US20060135560-A1

A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1-C4)alkyl, R1 and R2 are individually (C1-C4)alkyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 i ...


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David J Grainger, Paul R Kemp: Prevention and treatment of cardiovascular pathologies. Baker & Botts, February 9, 2006: US20060029986-A1

A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1-C4)alkyl, R1 and R2 are individually (C1-C4)alkyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 i ...


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Grainger David J, Metcalfe James C, Kunz Lawrence L, Kemp Paul R, Schroff Robert W, Weissberg Peter L: Prevention and treatment of cardiovascular pathologies with tamoxifen analogues. Neorx Corporation, Grainger David J, Metcalfe James C, Kunz Lawrence L, Kemp Paul R, Schroff Robert W, Weissberg Peter L, VIKSNINS Ann S, December 19, 1996: WO/1996/040098

A method for treating or preventing cardiovascular pathologies by administering a compound of formula (I), wherein Z is C=O or a covalent bond; Y is H or O(C¿1?-C¿4?)alkyl, R?1¿ and R?2¿ are individually (C¿1?-C¿4?)alkyl or together with N are a saturated heterocyclic group, R?3¿ is ethyl or chloroe ...