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Anna Borsodi, Zsuzsa Furst, Sandor Hosztafi, Schafferne E Varga, BuzaBeata, Tamas Friedmann, Sandor Benyhe, Maria Szucs: Pharmaceutical composition and use. Alkaloida Chemical Company, Steinberg Raskin & Davidson, May 31, 1994: US05317022 (70 worldwide citation)

A biologically active preparation for human or veterinary use for the selective blockade of opioid binding sites of the brain responsible for respiratory depression containing in a biologically active quantity the codeinone derivative of general formula (I) or its salt


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SHIOTANI MASAHARU, ISHIHARA TOMOMI, MATSUSHITA CHIAKI: [fr] UTILISATION COMBINÉE DE COMPOSÉ INHIBITEUR DE DIPEPTIDYLPEPTIDASE IV, ET DADOUCISSEUR, [de] KOMBINIERTE VERWENDUNG EINER DIPEPTIDYL-PEPTIDASE-IV-INHIBITOR-VERBINDUNG UND EINES SÜSSSTOFFS, [en] COMBINED USE OF DIPEPTIDYL PEPTIDASE IV INHIBITOR COMPOUND AND SWEETENER. MITSUBISHI TANABE PHARMA, January 13, 2010: EP2143443-A1 (35 worldwide citation)

[en] The present invention provides a novel therapeutic or preventive method, a pharmaceutical composition and use thereof, that exhibit superior anti-obesity effects (body weight-reducing (losing) effects and/or body fat mass-reducing effects). Specifically, the present invention provides a pharmac ...


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Michel Aletru, Alain Jean Braun, Claudie Namane, Olivier Venier, Christophe Philippo, Patrick Mougenot, Eric Nicolai, Stefan Gussregen: Urea derivatives of tropane, their preparation and their therapeutic application. Sanofi Aventis, Jiang Lin, March 1, 2011: US07897773 (30 worldwide citation)

The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).


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Tanaka Takaharu, Saitoh Masayuki, Hashimoto Masaki, Higuchi Naoki: N-acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use.. Suntory, November 20, 1986: EP0201742-A2 (23 worldwide citation)

A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an anti-amnesic agent that contains said compound as the active ingredient are provided.


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Iwakuma Takeo, Kawaguchi Takayuki, Yamashita Toyoharu Kitamot, Sasaki Yasuhiko, Shimazaki Tamotu: Phenoxyacetic acid compounds, their preparation, pharmaceutical composition and use.. Tanabe Seiyaku Co, February 10, 1988: EP0255728-A2 (18 worldwide citation)

Novel phenoxyacetic acid of the formula: wherein Ring A is phenylene group or a phenylene group having 1 to 2 substituent(s) selected from a lower alkyl group, a lower alkoxy group and a halogen atom; either one or two group(s) of R, R, R and R are a lower alkyl group, and the other groups are hydro ...


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Suda Hiroyuki C O Banyu Pharm, Kojiri Katuhisa C O Banyu Phar, Okura Akira C O Banyu Pharm Co, Kawamura Kenji C O Banyo Pharm, Okanishi Nasamori C O Banyu Ph: Phthalinide derivative, pharmaceutical composition and use.. Banyu Pharma, September 26, 1990: EP0388956-A2 (16 worldwide citation)

A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of producing the novel substance and a microorganism capable ...


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Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Yamatsu Isao, Kobayashi Seiichi, Shirota Hiroshi, Katayama Kouichi: 2-pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use.. Eisai, December 17, 1986: EP0204964-A1 (14 worldwide citation)

Disclosed is a novel 2-pyrrolidone derivative, including 3-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-2-pyrrolidone and an N-substituted one. The substituent includes alkyl, alkoxy, alkynyl, phenyl-alkylene, hydroxy-alkylene and amino-alkylene. It is effective as an anti-inflammatory, analgesic and a ...


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Kai Yu, Zhiwen Wang, Fuping Kou: L-threonate ferrous, as well as pharmaceutical composition and use for improving and treating human anemia thereof. Alston & Bird, November 6, 2001: US06313170 (11 worldwide citation)

A compound of ferrous L-threonate with structure (I), its compostions and methods useful for iron supplementation for mammals, particularly for human body to improve and treat nutritional iron-deficiency anemia, blood loss anemia and hemolytic anemia.