1
Leon WMM Terstappen, Ton Logtenberg: Phage antibodies. Becton Dickinson & Company, Crucell Holland, Irving N Feit, Hoffman & Baron, July 24, 2001: US06265150 (182 worldwide citation)

Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific for subsets of blood leucocytes by flow cytometry. Isolated phage antibodies showed exclusive binding to ...


2
Fibronectin as a tumor marker detected by phage antibodies. Crucell Holland, July 24, 2002: EP1224943-A1 (36 worldwide citation)

Means and method for at least partial inhibition of tumor growth are provided. Methods makes use of binding molecules capable of specifically binding to an epitope present on a subset of fibronectin proteins. By providing an individual with a binding molecule of the invention it is possible to inter ...


3
Alan Garen, Xiaohang Cai: Human monoclonal anti-tumor antibodies. Yale University, Mary M Krinsky, October 31, 2000: US06140470 (15 worldwide citation)

Human monoclonal anti-tumor antibodies are isolated from fusion phage single-chain Fv and V.sub.H antibody libraries constructed from the peripheral blood lymphocytes of immunized cancer patients. Antibodies that bind to tumor cells of the same kind as the patient's are selected, and antibodies that ...


4
Leon W M M Terstappen, Ton Logtenberg: Phage antibodies. Crucell Holland, Hoffmann & Baron, Irving N Feit, February 22, 2005: US06858384 (14 worldwide citation)

Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific for subsets of blood leucocytes by flow cytometry. Isolated phage antibodies showed exclusive binding to ...


5
Dennis E Hallahan, Raymond Mernaugh: Phage antibodies to radiation-inducible neoantigens. Vanderbilt University, Jenkins Wilson Taylor & Hunt P A, December 11, 2007: US07306925 (9 worldwide citation)

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more ...


6
Dennis E Hallahan, Raymond Mernaugh: Phage antibodies to radiation-inducible neoantigens. Vanderbilt University, September 6, 2011: US08012945 (5 worldwide citation)

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more ...


7
Dennis E Hallahan, Raymond Mernaugh: Phage antibodies to radiation-inducible neoantigens. Vanderbilt University, December 31, 2013: US08617521 (4 worldwide citation)

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more ...


8
Bin Liu, James D Marks: Internalizing human monoclonal antibodies targeting prostate cancer cells in situ. The Regents of the University of California, Tom Hunter, Weaver Austin Villeneuve & Sampson, October 21, 2014: US08865873 (4 worldwide citation)

This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented pr ...


9
Voest Emile Eugene, Bloemendal Henri Johan, de Boer Henriette Christine, Gebbink Martijn Frans Ben Gera, Logtenberg Ton: Activated vitronectin as a marker of angiogenesis detected with phage antibodies. Crucell Holland, September 5, 2001: EP1130099-A1 (3 worldwide citation)

The present invention provides a method for producing antibody fragments that discriminate between native and activated vitronectin, which can be used as markers of angiogenesis. Also provided are antibodies and peptides comprising said fragments, and therapeutic methods, particularly related to tar ...


10
Dorothy French, Erik Huntzicker, Christian W Siebel: Compositions and methods for diagnosis and treatment of hepatic cancers. Genentech, McNeill Baur PLLC, January 24, 2017: US09550829 (2 worldwide citation)

The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.