1
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. Hoffmann La Roche, George M Gould, William H Epstein, Catherine R Roseman, January 17, 1995: US05382657 (204 worldwide citation)

Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in v ...


2
Karasiewicz Robert, Nalin Carlo, Rosen Perry: Peg-interferon conjugates.. Hoffmann La Roche, April 27, 1994: EP0593868-A1 (74 worldwide citation)

The present invention relates to physiologically active water soluble polyethylene glycol conjugates with interferon and to new polyethylene glycol compounds which can be used in the preparation of the conjugates.


3
Cho Seong Hui, Lee Gang Chun: Antiviral agent containing substituted peg-interferon conjugates. Dong A Pharm, July 28, 2003: KR1020020002651 (2 worldwide citation)

PURPOSE: Provided is a pharmaceutical composition containing substituted PEG-interferon α conjugates as an effective ingredient for the treatment or prevention of interferon-susceptible diseases. CONSTITUTION: Substituted PEG-IFN α conjugates are represented by the formula(1). In formula ...


4
Karasiewicz Robert, Nalin Carlo, Rosen Perry: Conjugues peg-interferon, Peg-interferon conjugates. F Hoffmann La Roche, F Hoffmann La Roche, GOWLING LAFLEUR HENDERSON, April 8, 2003: CA2103829

The present invention relates to physiologically active water solublepolyethylene glycol conjugates with interferon and to new polyethyleneglycol compounds which can be used in the preparation of the conjugates.


5
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. F Hoffmann La Roche, WEN HONGYAN, February 18, 1998: CN97105434

The present invention relates to physiologically active water soluble polyethylene glycol conjugates with interferon and to new polyethylene glycol compounds which can be used in the preparation of the conjugates.


6
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. F Hoffmann La Roche, LIU YUANJIN WANG YANG, July 6, 1994: CN93116479

The present invention relates to physiologically active water soluble polyethylene glycol conjugates with interferon and to new polyethylene glycol compounds which can be used in the preparation of the conjugates.