1
Maurice Kent Gately, John Hakimi, Ping Ling: P-40 homodimer of interleukin-12. Hoffmann La Roche, George W Johnston, Dennis P Tramaloni, Alan P Kass, July 22, 1997: US05650492 (65 worldwide citation)

Analysis of the culture media of p40-transfected COS cells indicated the presence of 40 kDa monomers and 80 kDa disulfide-linked homodimers. Examination of partially purified p40 recombinant proteins demonstrated that only the homodimer but not the monomer binds to the IL-12 receptor. Partially puri ...


2
Gately Maurice Kent, Hakimi John, Ling Ping: P-40 homodimer of interleukin-12. F Hoffmann La Roche, February 28, 1995: JP1995-053594

PURPOSE: To provide a p-40 homodimer of interleukin-12 which comprises two mutually associated p-40 subunits of interleulin-12, acts as the antagonist of an interleukin-12 receptor, and is useful e.g. as a medicine for preventing or treating septic shock. CONSTITUTION: The objective homodimer compri ...