1
Takeru Higuchi, Harold M Leeper: Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, December 7, 1976: US03995631 (241 worldwide citation)

An osmotic active agent dispenser is comprised of a chamber having controlled permeability to an external fluid, i.e., water, and containing an osmotically effective solute which, in solution, exhibits an osmotic pressure gradient against said external fluid, said chamber housing a flexible bag of r ...


2
Masahiro Nakano, Takeru Higuchi, Anwar Hussain: Osmotic dispenser. Alza Corporation, Bacon & Thomas, December 7, 1976: US03995632 (140 worldwide citation)

An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the active agent formulation of which is a solid or semisolid at storage temperatures, advantageously room ...


3
Higuchi Takeru, Leeper Harold M: Osmotic dispenser. Alza Corporation, May 15, 1973: US3732865 (118 worldwide citation)

An osmotic active agent dispenser is comprised of (1) a first compartment of relatively impervious material containing an active agent and provided with an aperture for releasing said active agent to the exterior of the dispenser; (2) a second compartment of controlled permeability to water containi ...


4
Felix Theeuwes: Osmotic dispenser with gas generating means. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, July 19, 1977: US04036228 (113 worldwide citation)

An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding a compartment and has a passageway through the wall for dispensing the agent. The wall is formed of a material permeable to an external fluid and substantially impermeable to agent and a gas ...


5
Higuchi Takeru: Osmotic dispenser with collapsible supply container. Alza Corporation, September 25, 1973: US3760805 (98 worldwide citation)

An osmotic dispenser is comprised of (1) a water porous housing member confining (2) a first flexible bag of relatively impervious material containing an active agent and provided with active agent dispensing head, and (3) a second bag of controlled permeability to moisture containing a solution whi ...


6
Richard William Baker: Controlled release delivery system by an osmotic bursting mechanism. Bend Research, April 27, 1976: US03952741 (88 worldwide citation)

An osmotic dispenser comprised of (1) a water permeable membrane forming part or all of the walls of an enclosure surrounding (2) an active agent, and in some cases (3) an additional compound known as an osmotic attractant which together exhibits an osmotic pressure against water. When placed in an ...


7
Leeper Harold M: Helical osmotic dispenser with non-planar membrane. September 25, 1973: US3760806 (63 worldwide citation)

An osmotic active agent dispenser is comprised of: (1) a first helical compartment of relatively impervious material containing an active agent and provided with a dispensing head for releasing active agent to the exterior of the dispenser; (2) a second helical compartment of controlled permeability ...


8
Higuchi Takeru, Leeper Harold M: Improved osmotic dispenser employing magnesium sulphate and magnesium chloride. Alza Corporation, September 25, 1973: US3760804 (59 worldwide citation)

An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the motive force of which dispenser depends on the osmotic pressure developed by either (1) an aqueous solu ...


9
David Edgren: Drug dispenser comprising wall formed of semipermeable member and enteric member. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, June 11, 1985: US04522625 (50 worldwide citation)

An osmotic dispenser is disclosed for releasing drug formulation in the gastrointestinal tract. The dispenser comprises a semipermeable-enteric wall surrounding a compartment housing drug formulation. A passageway in the wall communicates with the compartment for dispensing drug formulation.


10
Higuchi Takeru: Osmotic dispenser. Alza Corporation, Bacon & Thomas, December 30, 1975: US3929132 (43 worldwide citation)

An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the active agent content of which dispenser is formulated in a form other than wholly in solution, namely, ...