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Berdini Valerio, Boyle Robert George, Saxty Gordon, Verdonk Marinus Leendert, Woodhead Steven John, Wyatt Paul Graham, Sore Hannah Fiona, Caldwell John, Collins Ian, Da Fonseca Tatiana Faria, Donald Alastair: Ortho- condensed pyridine and pyrimidine derivatives (e. g. purines) as protein kinases inhibitors. Astex Therapeutics, Cancer Res Inst Royal, Cancer Rec Tech, August 1, 2007: EP1812003-A1

The invention provides a compound for use in the prophylaxis or treatment of a disease state or condition mediated by protein kinase B, the compound having the formula (I): or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR; J-J is N=C(R), (R)C=N, (R)N-C(O), (R)2C-C(O), N=N or ( ...


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Berdini Valerio, Boyle Robert George, Saxty Gordon, Walker David Winter, Woodhead Steven John, Wyatt Paul Graham, Caldwell John, Collins Ian, Da Fonseca Tatiana Faria, Donald Alastair: Ortho- condensed pyridine and pyrimidine derivatives (e. g. purines) as protein kinases inhibitors. Astex Therapeutics, Cancer Res Inst Royal, Cancer Rec Tech, August 1, 2007: EP1812004-A1

The invention provides a compound for use as a protein kinase B inhibitor, the compound being a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR; J-J is N=C(R), (R)C=N, (R)N-C(O), (R)2C-C(O), N=N or (R)C=C(R); E is a monocyclic carbocyclic or hetero ...


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