41
Erik Christopher Chelius, Susan Marie Reutzel Edens, Sharon Van den Berghe Snorek: Crystalline of N-[4-[2-(2-Amino-4,7-dihydro-4oxo-3H-pyrrolo[2,3-D]pyrimidin-5-YL)ethyl]benzoyl]-L-glutamic acid and process therefor. Eli Lilly and Company, Elizabeth A McGraw, Manisha A Desai, November 21, 2006: US07138521 (7 worldwide citation)

The invention relates to the field of pharmaceutical and organic chemistry and provides an improved process for preparing the novel heptahydrate crystalline salt of multitargeted antifolate N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid.


42
Leimgruber Willy, Wick Alexander E: Process for the methylenation of catechols. Hoffmann La Roche, Welt Samuel L, Leon Bernard S, Hoffman Frank P, November 25, 1975: US3922285 (7 worldwide citation)

A method for the methylenation of catechols via the reaction of catechols with methylene chloride in the presence of selected strong bases is described. This process has wide applicability in the field of synthetic organic chemistry, especially in natural product syntheses.


43
Jindrich Jindrich, Antonin Holy: Di(2-propyl)esters of 1-fluoro-2-phosphonomethoxy-3-P-to-luenesulfonyloxypropanes, their producing and utilization. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Max D Hensley, October 4, 1994: US05352786 (7 worldwide citation)

The invention relates to new compounds, di(2-propyl) esters of (R)-, (S)- and (RS)-1-fluoro-2-phosphonomethoxy-3-p-toluenesulfonyloxypropane and the method of producing them. The compounds can be used with advantage in the preparation of N-(3-fluoro-2-phosphonomethoxypropyl) derivatives of heterocyc ...


44
Beigelman Leonid, Blatt Lawrence, Lonnberg Harri: 2-5a analogs and their methods of use. Alios Biopharma, Beigelman Leonid, Blatt Lawrence, Lonnberg Harri, ARNO Thomas R, August 7, 2008: WO/2008/095040 (7 worldwide citation)

This invention relates to the fields of organic chemistry, pharmaceutical chemistry, biochemistry, molecular biology and medicine. In particular it relates to compounds that activate RNaseL, and to the use of the compounds for treating and/or ameliorating a disease or a condition, such as a viral in ...


45
Jeffery A Whiteford, William Freeman, Joshua W Kriesel: Bridged macrocyclic module compositions. Covalent Partners, Finnegan Henderson Farabow Garrett & Dunner, May 6, 2008: US07368564 (6 worldwide citation)

This invention is related to the fields of organic chemistry and nanotechnology. In particular, it relates to materials and methods for the preparation of organic synthons and bridged macrocyclic module compounds. The bridged macrocyclic module compounds may be used to prepare macrocyclic compositio ...


46
Lu Long, Chen Jie, Wu Yong, Jin Zhiping, Xu Xiaoyan, Yuan Jun, Zhang Yan, Wang Yonghua: 2-pyrimidionxy-n-carbamidophenylbenzylamine compounds and processes of the preparation thereof and the use of the same. Shanghai Institute Of Organic Chemistry Chinese Academy Of Sciences, Zhejiang Chem Tech Group, Bayer Cropscience, Lu Long, Chen Jie, Wu Yong, Jin Zhiping, Xu Xiaoyan, Yuan Jun, Zhang Yan, Wang Yonghua, SHANGHAI ZHI XIN PATENT AGENT, July 28, 2005: WO/2005/068434 (6 worldwide citation)

The present invention disclosed a series of 2-pyrimidionxy-N-carbamidophenylbenzylamine compounds and processes of the preparation thereof and the herbicide use of the same. The compounds represented by the following formula (I), wherein D or E is hydrogen, halogen, C1-C4 alkyl, C1-C4 akloxy, C1-C4 ...


47
Andrei Darievich Mirzabekov, Alla Jurievna Rubina, Sergei Vasilievich Pankov: Composition for polymerizing immobilization of biological molecules and method for producing said composition. Institut Molekulyarnoi Biologii IM V A Engelgardta Rossiiskoi Akademii Nauk, Ladas & Parry, December 7, 2010: US07846656 (5 worldwide citation)

The invention refers to the field of molecular biology and bio-organic chemistry and deals with a composition for immobilization in polymer carriers of oligonucleotides, proteins, nucleic acids or any other molecules, which structure comprises active groups, including amino- or sulfhydryl groups, as ...


48
Purushotham Vemishetti, Paul R Brodfuehrer, Henry G Howell, Chester Sapino Jr: Process for the preparation of nucleotides. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, January 7, 1997: US05591852 (5 worldwide citation)

The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.


49
Stephen D Darling, Aloysius A Jendrisak, David J Bokmiller: Molecular model for chemistry. Tacoma Products, James A Hudak, August 16, 1983: US04398888 (5 worldwide citation)

A molecular model building set for the formation of models of molecules and compounds primarily in the field of organic chemistry is disclosed. The set includes dimensionally accurate model building members (10, 60) that are rotatable about their axes, and can be interconnected and/or interlocked to ...


50
Dietrich Arntz, Gunter Prescher, Werner Burkhardt, Johannes Heilos, Reinhard Manner: Process for preparing aromatic nitriles. Degussa Aktiengesellschaft, Beveridge DeGrandi & Weilacher, September 3, 1985: US04539409 (5 worldwide citation)

A process is disclosed for preparing coated catalysts, inter alia, for gas phase oxidations in organic chemistry, comprised of an inert support and a coating of catalyst material enclosing this support, wherein a suspension of the starting material for the coating is sprayed onto an agitated bed of ...



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