1
Kolb Michael, Burkhart Joseph P, Jung Michel J, Gerhart Fritz E, Giroux Eugene L, Schirlin Daniel G, Neises Bernhard: Novel peptidase inhibitors.. Merrell Dow Pharma, September 24, 1986: EP0195212-A2 (127 worldwide citation)

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of ...


2
Bey Philippe, Angelastro Michael, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, April 11, 1990: EP0363284-A2 (98 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide gorup of the substrate peptide has been replaced by H or a substituted carbonyl moiety. The contemplated peptidase inhibitors of the foregoing enzymes are selected from the generic formula R1NH ...


3
Bey Philippe, Angelastro Michael, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, April 18, 1990: EP0364344-A2 (90 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by a substituted malonyl moiety. The contemplated peptidase inhibitors of the foregoing enzymes are selected from the generic formula the hydrat ...


4
Bey Philippe, Peet Norton P, Angelastro Michael R, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, January 30, 1991: EP0410411-A2 (81 worldwide citation)

This invention relates to activated electrophilic ketone analogs of certain peptidase substrates which are useful in inhibiting serine-, carboxylic acid- and metallo- proteolytic enzymes, the inhibition of which will have useful physiological consequences in a variety of disease states.


5
Schirlin Daniel, Pelton John Tom, Tarnus Celine, Jung Michel: Novel peptidase inhibitors.. Merrell Dow Pharma, April 4, 1990: EP0362002-A1 (33 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of pro ...


6
Schirlin Daniel, Jung Michel: Novel peptidase inhibitors.. Merrell Dow Pharma, July 20, 1988: EP0275101-A2 (32 worldwide citation)

This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent proteolytic enzymes, the inhibition of which ...


7
Schirlin Daniel, Pelton John Tom, Tarnus Celine, Jung Michel: Novel peptidase inhibitors.. Merrell Dow Pharma, March 7, 1990: EP0356595-A1 (7 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of pro ...


8
Bey Philippe, Angelastro Michael, Mehdi Shujaath: Nouveau inhibiteurs de la peptidase, Novel peptidase inhibitors. Aventis Pharma, OSLER HOSKIN & HARCOURT, October 3, 2000: CA2000342

This invention relates to analogs of peptidase substratesin which the nitrogen atom of the scissile amide group of thesubstrate peptide has been replaced by H or a substitutedcarbonyl moiety. These analogs of the peptidase substratesprovide specific enzyme inhibitors for a variety of proteases,the i ...


9
Michael Angelastro, Philippe Bey, Shujaath Mehdi: Novel peptidase inhibitors. Merrell Dow Pharmaceuticals, TIANG YUE, May 9, 1990: CN89107700

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by H, an aldehyde, a substituted carbonyl or a substituted malonyl moiety. These analogs of the peptidase substrates provide specific enzyme inh ...


10
Daniel Schirlin: Novel peptidase inhibitors. Merrell Dow Pharmaceuticals, TIANG YUE, March 21, 1990: CN89106655

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of pro ...