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Egbertson Melissa S, Hartman George D, Halczenko Wasyl, Laswell William L: Novel fibrinogen receptor antagonists.. Merck & Co, April 1, 1992: EP0478328-A1 (101 worldwide citation)

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.


2
George D Hartman, Wasyl Halczenko: Fibrinogen receptor antagonists. Merck & Co, Charles M Caruso, Richard S Parr, Monte R Browder, July 13, 1993: US05227490 (41 worldwide citation)

Novel fibrinogen receptor antagonists of the formula ##STR1## are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.


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George D Hartman, John D Prugh, Melissa S Egbertson, Mark E Duggan, William Hoffman: Fibrinogen receptor antagonists. Merck & Co, Richard S Parr, Melvin Winokur, July 28, 1998: US05786373 (14 worldwide citation)

Novel fibrinogen receptor antagonists of the formula: X--Y--Z-Aryl-A--B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsubstituted or substituted with R.sup.5 and whe ...


5
George D Hartman, Wasyl Halczenko: Fibrinogen receptor antagonists. Merck & Co, Richard S Parr, Mel Winokur, Paul D Matukaitis, October 25, 1994: US05358956 (6 worldwide citation)

Novel fibrinogen receptor antagonists of the formula: ##STR1## are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.


6
Weisenberger Johannes, Schubert Hans Dieter, Switek Karl Heinz, Linz Guenter, Himmelsbach Frank: Labelled fibrinogen-receptor-antagonists, their use and their production.. Thomae Dr K, November 3, 1993: EP0567967-A1 (4 worldwide citation)

The present invention relates to novel fibrinogen receptor antagonists labelled with a detectable atom, which have a comparable or higher affinity for the receptor than I-fibrinogen and whose binding is not impaired by foreign proteins, in particular the tritium-labelled fibrinogen receptor antagoni ...


7
Egbertson Melissa S, Turchi Laura M, Hartman George D, Halczenko Wasyl, Whitman David B, Perkins James J, Krause Amy E W Dekalb Pike, Ihle Nathan, Claremon David Alan, Hoffman William, Duggan Mark E: Fibrinogen receptor antagonists.. Merck & Co, September 27, 1995: EP0673247-A1

Novel fibrinogen receptor antagonists of the formula: X-Y-Z-Aryl-A-B are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.


8
Hartman George D, Halczenko Wasyl: Fibrinogen receptor antagonists. Merck & Co, sBROWDER Monte R, September 2, 1993: WO/1993/016697

Novel fibrinogen receptor antagonists of formula (I) are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.


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Hartman George D, Prugh John D, Egbertson Melissa S, Duggan Mark E, Hoffman William: Fibrinogen receptor antagonists. Merck & Co, Hartman George D, Prugh John D, Egbertson Melissa S, Duggan Mark E, Hoffman William, PARR Richard S, April 28, 1994: WO/1994/008577

Novel fibrinogen receptor antagonists of the formula: X-Y-Z-Aryl-A-B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsubstituted or substituted with R?5¿ and wherein S ...


10
Egbertson Melissa S, Turchi Laura M, Hartman George D, Halczenko Wasyl, Whitman David B, Perkins James J, Krause Amy E, Ihle Nathan, Claremon David Alan, Hoffman William, Duggan Mark E: Fibrinogen receptor antagonists. Merck & Co, Egbertson Melissa S, Turchi Laura M, Hartman George D, Halczenko Wasyl, Whitman David B, Perkins James J, Krause Amy E, Ihle Nathan, Claremon David Alan, Hoffman William, Duggan Mark E, PARR Richard S, June 9, 1994: WO/1994/012181

Novel fibrinogen receptor antagonists of the formula: X-Y-Z-Aryl-A-B are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.