1
Abraham J Domb, Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia, Robert S Langer: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, December 28, 1999: US06007845 (332 worldwide citation)

Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of a multiblock copolymer formed by covalently l ...


2
Abraham J Domb, Ruxandra Gref, Yoshiharu Minamitake, Maria T Peracchia, Robert S Langer: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, November 26, 1996: US05578325 (164 worldwide citation)

Injectable particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified as necessary to achieve variable release rates or to target specific cells or organs as desired. The injectable particles can include ma ...


3
Domb Abraham J, Gref Ruxandra, Minamitake Yoshiharu, Peracchia Maria Teresa, Langer Robert S: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Institute of Technology, Domb Abraham J, Gref Ruxandra, Minamitake Yoshiharu, Peracchia Maria Teresa, Langer Robert S, PABST Patrea L, February 2, 1995: WO/1995/003356 (1 worldwide citation)

Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of a multiblock copolymer formed by covalently l ...


4
Domb Abraham J, Gref Ruxandra, Minamitake Yoshiharu, Peracchia Maria Teresa, Langer Robert S: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Inst Technology, May 22, 1996: EP0712421-A1

Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of a multiblock copolymer formed by covalently l ...


5
SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION. C4 Theraprutics, March 14, 2019: US20190076540-A1

This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their pre ...


6
C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION. C4 Theraprutics, March 14, 2019: US20190076542-A1

This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.


7
HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION. C4 Theraprutics, March 14, 2019: US20190076541-A1

This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for ...


8
PYRIMIDINE-BASED ANTIPROLIFERATIVE AGENTS. G1 Therapeutics, May 9, 2019: US20190135811-A1

This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.