1
James Aggen, John H Griffin, Mathai Mammen, Daniel Marquess, Edmund J Moran, David Oare: Muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Joyce G Cohen, February 17, 2004: US06693202 (123 worldwide citation)

Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modu ...


2
Mathai Mammen, David Oare: Therapeutic ureas. Theravance, Jeffrey A Hagenah, David E Boone, October 21, 2003: US06635764 (76 worldwide citation)

This invention relates to urea compounds that are muscarinic receptor antagonists and agonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds.


3
Peter E Cross, Alexander R MacKenzie: Pyrrolidine derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Seymore G Bekelnitzky, March 17, 1992: US05096890 (35 worldwide citation)

Compounds of the formula ##STR1## wherein R, Y and R.sup.1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altere ...


4
Mathai Mammen, Yu Hua Ji, YongQi Mu, Craig Husfeld, Li Li: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, October 30, 2007: US07288657 (34 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compo ...


5
Mathai Mammen, Yu Hua Ji, YongQi Mu, Craig Husfeld, Li Li: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, September 4, 2007: US07265133 (30 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, process ...


6
Mathai Mammen, Yu Hua Ji, YongQi Mu, Eric L Stangeland, Aaron Kushner, Craig Husfeld: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, August 28, 2007: US07262205 (27 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, pr ...


7
Peter E Cross, Alexander R MacKenzie: Muscarinic receptor antagonists. Pfizer, Peter C Richardson, Paul H Ginsburg, Garth Butterfield, August 23, 1994: US05340831 (27 worldwide citation)

Muscarinic receptor antagonists of formula (I), and their pharmaceutically acceptable salts, wherein Y is --CH.sub.2 --, --(CH.sub.2).sub.2 --, --CH.sub.2 O--, --(CH.sub.2).sub.2 O-- or --CH.sub.2 S--; R is --CH or --CONH.sub.2 ; and R.sup.1 is a group of formula (a), where R.sup.2 and R.sup.3 are e ...


8
David Alker, Peter E Cross: Piperidine and pyrrolidine derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Garth Butterfield, September 6, 1994: US05344835 (24 worldwide citation)

According to the invention there is provided a compound of formula (I): R.sup.1 --O(CH.sub.2).sub.m A(CH.sub.2).sub.n XR or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is a group of formula (a or b) where Z is --(CH.sub.2).sub.2-, --CH.dbd.CH--, --CH.sub.2 --S-- or --CH.sub.2 --O--; ...


9
Peter E Cross, Alexander R MacKenzie: Pyrrolidine derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Seymour G Bekelnitzky, August 3, 1993: US05233053 (24 worldwide citation)

Compounds of the formula ##STR1## wherein R, Y and R.sup.1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altere ...


10
Yu Hua Ji, Craig Husfeld, Mathai Mammen, YongQi Mu, Eric L Stangeland: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, January 20, 2009: US07479562 (23 worldwide citation)

The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermed ...



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