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Dorn Conrad P, Hale Jeffrey J, Maccoss Malcolm, Mills Sander G, Ladduwahetty Tamara, Shah Shrenik K: Morpholine and thiomorpholine tachykinin receptor antagonists.. Merck & Co, January 5, 1994: EP0577394-A1 (78 worldwide citation)

Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.


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Conrad P Dorn, Paul E Finke, Jeffrey J Hale, Malcolm MacCoss, Sander G Mills, Shrenik K Shah, Mark Stuart Chambers, Timothy Harrison, Tamara Ladduwahetty, Brian John Williams: Morpholine and thiomorpholine tachykinin receptor antagonists. Merck & Co, J Eric Thies, David L Rose, February 17, 1998: US05719147 (66 worldwide citation)

Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertensi ...


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Conrad P Dorn, Paul E Finke, Jeffrey J Hale, Malcolm Maccoss, Sander G Mills, Shrenik K Shah, Mark Stuart Chambers, Timothy Harrison, Tamara Ladduwahetty, Brian John Williams: Morpholine and thiomorpholine tachykinin receptor antagonists. Merck & Co, J Eric Thies, David L Rose, February 16, 1999: US05872116 (7 worldwide citation)

Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertensi ...


4
Conrad P Dorn, Paul E Finke, Jeffrey J Hale, Malcolm Maccoss, Sander G Mills, Shrenik K Shah, Mark Stuart Chambers, Timothy Harrison, Tamara Ladduwahetty, Brian John Williams: Morpholine and thiomorpholine tachykinin receptor antagonists. Merck & Co, J Eric Thies, David L Rose, April 11, 2000: US06048859 (6 worldwide citation)

Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertensi ...


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Conrad P Dorn, Jeffrey J Hale, Malcolm Maccoss, Sander G Mills, Shrenik K Shah, Tamara Ladduwahetty: Morpholine and thiomorpholine tachykinin receptor antagonists. Merck & Co, J Eric Thies, David L Rose, July 13, 1999: US05922706 (2 worldwide citation)

Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertensi ...


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Dorn Conrad P, Finke Paul E, Hale Jeffrey J, Maccoss Malcolm, Mills Sander G, Shah Shrenik K, Chambers Mark Stewart, Harrison Timothy, Ladduwahetty Tamara, Williams Brian John: Antagonistes de recepteurs des tachykinines, a base de morpholine et thiomorpholine, Morpholine and thiomorpholine tachykinin receptor antagonists. Merck & Co, Merck & Co, OGILVY RENAULT SENCRLSRL, June 22, 1995: CA2178949

Substituted heterocycles of general structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of: hydrogen; C1-6 alkyl, unsubstituted or substituted; C2-6 alkenyl, unsubstituted or substituted; C2-6 alkynyl; phenyl, unsubstitued or substi ...