1
Tirtha Chakraborty, Antonin de Fougerolles: Modified polynucleotides for the production of secreted proteins. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, November 24, 2015: US09192651 (7 worldwide citation)

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.


2

3

4
Tirtha Chakraborty, Stephane Bancel, Stephen G Hoge, Atanu Roy, Antonin de Fougerolles, Noubar B Afeyan: Terminally modified RNA. ModernaTx, Nelson Mullins Riley & Scarborough, Amy E Mandragouras Esq, March 21, 2017: US09597380

The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.


5
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M Wood, Paul Hatala, Jason P Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild: Modified polynucleotides for the production of oncology-related proteins and peptides. ModernaTX, Clark & Elbing, March 7, 2017: US09587003

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.


6
Yuxun Wang, Divakar Ramakrishnan, Antonin De Fougerolles, Susan Whoriskey: Enzymes and polymerases for the synthesis of RNA. ModernaTX, Wolf Greenfield & Sacks P C, October 17, 2017: US09790531

The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.


7
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS. MODERNA THERAPEUTICS, October 3, 2013: US20130259923-A1

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.


8
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS. December 29, 2016: US20160375134-A1

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.


9
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS. February 2, 2017: US20170028085-A1

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.


10
ENZYMES AND POLYMERASES FOR THE SYNTHESIS OF RNA. ModernaTX, May 11, 2017: US20170130255-A1

The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.