1
Lawrence M Blatt, Scott D Seiwert, Leonid Beigelman, Ramachandran Radhakrishnan, Karl Kossen, Vladimir Serebryany: Method of modulating stress-activated protein kinase system. Intermune, Marshall Gerstein & Borun, John Bendrick, June 1, 2010: US07728013 (18 worldwide citation)

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentag ...


2
Seiwert Scott D, Kossen Karl, Serebryany Vladimir: Method of modulating stress-activated protein kinase system. Intermune, Seiwert Scott D, Kossen Karl, Serebryany Vladimir, LILY RIN LAURES, May 31, 2007: WO/2007/062167 (11 worldwide citation)

It has now been discovered that a high therapeutic effect in treating various disorders associated with enhanced activity of kinase p38 may be achieved by using a potent p38? kinase inhibitor compound which also has inhibitory activity against p38?. Furthermore, reducing the activities of both kinas ...


3
Lawrence M Blatt, Scott D Seiwert, Leonid Beigelman, Ramachandran Radhakrishnan, Karl Kossen, Vladimir Serebryany: Method of modulating stress-activated protein kinase system. Intermune, Knobbe Martens Olson & Bear, June 3, 2014: US08741936 (6 worldwide citation)

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentag ...


4
Lawrence M Blatt, Scott D Seiwert, Leonid D Beigelman, Ramachandran Radhakrishnan, Karl Kossen, Vladimir Serebryany: Method of modulating stress-activated protein kinase system. InterMune, Knobbe Martens Olson & Bear, December 27, 2016: US09527816 (1 worldwide citation)

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentag ...


5
Lawrence M Blatt, Scott D Seiwert, Leonid D Beigelman, Ramachandran Radhakrishnan, Karl Kossen, Vladimir Serebryany: Method of modulating stress-activated protein kinase system. INTERMUNE, Marshall Gerstein & Borun, July 3, 2018: US10010536

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentag ...


6
Seiwert Scott D, Kossen Karl, Serebryany Vladimir: Method of modulating stress-activated protein kinase system. Intermune, liu dong fu lei, February 4, 2009: CN200680051489

It has now been discovered that a high therapeutic effect in treating various disorders associated with enhanced activity of kinase p38 may be achieved by using a potent p38 gamma kinase inhibitor compound which also has inhibitory activity against p38gamma. Furthermore, reducing the activities of b ...


7
SEIWERT SCOTT D, KOSSEN KARL, SEREBRYANY VLADIMIR: Method of modulating stress-activated protein kinase system, Verfahren zur Modulierung eines stressaktivierten Proteinkinasesystems, Méthode de modulation dun système de protéine kinase activée par le stress. INTERMUNE, March 7, 2012: EP2426134-A2

It has now been discovered that a high therapeutic effect in treating various disorders associated with enhanced activity of kinase p38 may be achieved by using a potent p38? kinase inhibitor compound which also has inhibitory activity against p38?. Furthermore, reducing the activities of both kinas ...


8
Seiwert Scott D, Kossen Karl, Serebryany Vladimir: Method of modulating stress-activated protein kinase system. Intermune, August 27, 2008: EP1960405-A2

It has now been discovered that a high therapeutic effect in treating various disorders associated with enhanced activity of kinase p38 may be achieved by using a potent p38? kinase inhibitor compound which also has inhibitory activity against p38?. Furthermore, reducing the activities of both kinas ...


9
Lawrence M Blatt, Scott D Seiwert, Leonid Beigelman, Ramachandran Radhakrishnan: Method of modulating stress-activated protein kinase system. Knobbe Martens Olson & Bear, November 30, 2006: US20060270612-A1

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentag ...


10
Lawrence M Blatt, Scott D Seiwert, Leonid Beigelman, Ramachandran Radhakrishnan, Karl Kossen, Vladimir Serebryany: Method of modulating stress-activated protein kinase system. Marshall Gerstein & Borun, September 23, 2010: US20100240704-A1

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentag ...