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Raju Kucherlapati, Aya Jakobovits: Method of making transgenic mice lacking endogenous heavy chains. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, August 17, 1999: US05939598 (541 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


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SYSTEMS FOR DETECTING, MONITORING OR TREATING DISEASES OR CONDITIONS USING ENGINEERED CELLS AND METHODS FOR MAKING AND USING THEM. October 18, 2018: US20180298340-A1

Provided are methods for detecting and treating disease states, including cancer, diabetes, fibrosis, and autoimmune diseases, by detecting increased mechanical modulus, or stiffness, or targeting tissues having increased mechanical modulus, or stiffness. Practicing these methods provides specific a ...