1
Peter C Cheeseman: Method for sequencing polynucleotides. Beckman Instruments, William H May, P R Harder, Janis C Henry, April 12, 1994: US05302509 (453 worldwide citation)

A method is provided for determining the sequence of nucleotides on a single strand DNA molecule. The single strand DNA molecule is attached to a leader oligonucleotide and its complementary strand to a solid state support. Fluorescently-labeled 3'-blocked nucleotide triphosphates, with each of the ...


2
Thomas M Brennan: Apparatus for determining DNA sequences by mass spectrometry. Genomyx, Allegretti & Witcoff, December 29, 1992: US05174962 (84 worldwide citation)

This invention relates to the apparatus, for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (adenine, guanine, cytosine or thymine) is a ...


3
Thomas M Brennan: Determining DNA sequences by mass spectrometry. Genomyx, Allegretti & Witcoff, March 26, 1991: US05003059 (78 worldwide citation)

This invention relates to the methods, apparatus, reagents and mixtures of reagents for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (a ...


4
Jingyue Ju, Zengmin Li, John Robert Edwards, Yasuhiro Itagaki: Massive parallel method for decoding DNA and RNA. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, John P White, Gary J Gershik, Cooper & Dunham, August 1, 2017: US09719139 (1 worldwide citation)

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotid ...


5
Jingyue Ju, Zengmin Li, John Robert Edwards, Yasuhiro Itagaki: Massive parallel method for decoding DNA and RNA. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, John P White, Gary J Gershik, Cooper & Dunham, August 8, 2017: US09725480 (1 worldwide citation)

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotid ...


6
Jingyue Ju, Zengmin Li, John Robert Edwards, Yasuhiro Itagaki: Massive parallel method for decoding DNA and RNA. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, John P White, Gary J Gershik, Cooper & Dunham, August 1, 2017: US09718852 (1 worldwide citation)

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotid ...


7
Balasubramanian Shankar: Polynucleotide sequencing. Solexa, Balasubramanian Shankar, GILL JINNINGS Broadgate House7 Eldon StreetLondon EC2M 7LH, April 5, 2001: WO/2001/023610 (1 worldwide citation)

A method for sequencing polynucleotides involves sequential addition of detectably labelled bases. A labelled base is incorporated by a polymerase onto a nascent strand, and, after detection, the polymerase is induced to replace the terminal labelled base with a corresponding unlabelled base, thereb ...


8
Jingyue Ju, Zengmin Li, John Robert Edwards, Yasuhiro Itagaki: Massive parallel method for decoding DNA and RNA. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, John P White, Cooper & Dunham, January 16, 2018: US09868985

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotid ...


9
Mark A Akeson, David W Deamer, William B Dunbar, Roger Jinteh Arrigo Chen, Noah A Wilson: Nucleotide sequencing using an array of independently addressable nanopores. The Regents of the University of California, Brian E Davy, Bozicevic Field & Francis, September 25, 2018: US10081835

Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using ...


10
George M Church, Gregory J Porreca, Jay Shendure, Abraham Meir Rosenbaum: Nanogrid rolling circle DNA sequencing. President and Fellows of Harvard College, Banner & Witcoff, April 18, 2017: US09624538

The present invention relates to methods for sequencing a polynucleotide immobilized on an array having a plurality of specific regions each having a defined diameter size, including synthesizing a concatemer of a polynucleotide by rolling circle amplification, wherein the concatemer has a cross-sec ...