51
Jim Haralambidis: Nucleoside derivatives. Howard Florey Institute of Experimental Physiology and Medicine, Sughrue Mion Zinn Macpeak & Seas, September 3, 1996: US05552540 (235 worldwide citation)

A nucleoside derivative of formula (1), characterized in that: Y is H or OH or a protected hydroxy group; X is H, a phosphonate group or a phosphoramidite group of formula (II), where R.sup.1 and R.sup.2 are the same or different, and are selected from alkyl and substituted alkyl, which may be branc ...


52
James S Burns, Daniel R Marshak: Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means. Armstrong Pharmaceuticals, Whitham & Marhoefer, February 8, 1994: US05284133 (233 worldwide citation)

An inhalation device is provided with a mechanism to assure patient compliance with a drug dosage regimen. The control mechanism includes a controller (24), a timer (26), an actuator (28) and a signalling device (30). The controller (24) is programmed or preset with a time and dosage schedule for th ...


53
Swaminathan Jayaraman: Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use. Iowa India Investments Company of Douglas, Pennie & Edmonds, May 2, 2000: US06056722 (229 worldwide citation)

The present invention preferably includes a balloon catheter for use with a guidewire. The catheter has a body with a balloon located thereon, preferably at the distal end. A lumen within the catheter body communicates with the interior of the balloon which can be inflated by known methods with sali ...


54
Christian Enggaard: Automatic injection device with reset feature. Novo Nordisk, Marc A Began Esq, Richard W Bork Esq, Reza Green Esq, May 31, 2005: US06899699 (229 worldwide citation)

The present invention relates to a dose setting and expelling device comprising a drive member and a dose setting mechanism which simultaneously sets a given dose and stores the energy necessary for a subsequently driving the drive member in order to expel a dose of medicine from an injection device ...


55
Henry R Halperin, Ronald D Berger, Ergin Atalar, Elliot R McVeigh, Albert Lardo, Hugh Calkins, Joao Lima: Magnetic-resonance-guided imaging, electrophysiology, and ablation. Johns Hopkins University School of Medicine, Foley Hoag, March 2, 2004: US06701176 (224 worldwide citation)

A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic res ...


56
Robert Logan Avery, Jeffrey Kevin Luttrull: Intravitreal medicine delivery. Leo F Costello, June 26, 2001: US06251090 (223 worldwide citation)

An intravitreal medicine delivery device and method are provided and include an implant device through which a wide variety of beneficial medicines including drugs or other pharmacological agents can be introduced into the vitreous cavity over an extended period of time with only a single initial su ...


57
Arthur E Colvin Jr: Optical-based sensing devices. Sensors for Medicine and Science, Rothwell Figg Ernst & Manbeck, March 23, 2004: US06711423 (222 worldwide citation)

An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surfac ...


58
Razgulov Mikhail Mikhailovich, Potekhina Lidia Alexandrovna, Mashinistov Boris Fedorovich: Device for the eversion of hollow organs and vascular stapling instrument incorporating same. Waters Schwartz & Nissen, September 30, 1975: US3908662 (222 worldwide citation)

The present invention relates to the field of medicine, and more particularly to vascular surgery, with particular reference to a device for the eversion of hollow organs and a vascular stapling instrument.According to the invention, a device for the eversion of hollow organs, comprising a bush, whe ...


59
Robert S Biscup: Spinal fusion implant. DePuy AcroMed, Fay Sharpe Fagan Minnich & McKee, January 13, 2004: US06676703 (217 worldwide citation)

An improved prosthetic implant for forming a rigid structure between adjoining vertebrae in a spinal column. The prosthetic implant includes a cage having a top, bottom, front end, back end, first side and second side walls. The first side wall has an arcuate surface. The top and bottom wall include ...


60
Valery Ivanovich Kobozev: Electrical gastro-intestinal tract stimulator. Sherman D Pernia, September 17, 2002: US06453199 (214 worldwide citation)

The invention relates to medicine specifically to medical technology, and concerns electrical gastro-intestinal tract and mucous membrane stimulators. The electrical gastro-intestinal tract stimulator comprises a casing (



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