41
Luigi Valentini, Mario Coccia: Safety device for connection of a syringe with the mouth or opening of a bottle containing a drug or a small tube for drug delivery from the syringe. Farmitalia Carlo Erba S p A, Oblon Fisher Spivak McClelland & Maier, March 18, 1986: US04576211 (246 worldwide citation)

The invention relates to a device to one end of which a syringe can be connected and to the other end of which the mouth or opening of a bottle containing a drug or medicine can be connected. The device comprises a closed chamber having enclosed therein a needle which is in connection with the syrin ...


42
Patricia A Broderick: Cathodic electrochemical current arrangement with telemetric application. Research Foundation The City University of New York, Morgan & Finnegan, November 28, 1989: US04883057 (242 worldwide citation)

This invention relates to a method for producing a cathodic, or reduction, current used in an in vivo semidifferential, semiderivative and/or semiintegral electrochemical method for achieving routine, reliable, and reproducible measurements of the dynamics of neurochemicals and neurochemical-like ma ...


43
Ralph S Greco, Richard A Harvey, Stanley Z Trooskin: Drug bonded prosthesis and process for producing same. University of Medicine and Dentistry of New Jersey, Klauber & Jackson, November 7, 1989: US04879135 (240 worldwide citation)

There is disclosed an improved prosthesis coated, respectively, with an anionic surfactant, a drug such as an antibiotic and/or antithrombotic agent. Optionally, the coated prosthesis may be treated with an ion exchange compound, to remove un-drug bound anionic surfactant. The drug is bound directly ...


44
Lisa B Shih, Frederick J Primus, Milton D Goldenberg: Tumoricidal methotrexate-antibody conjugate. Center for Molecular Medicine & Immunology, Bernhard D Saxe, October 13, 1987: US04699784 (239 worldwide citation)

A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.


45
Lily Chen Tu, Hosheng Tu: Ablation catheter and methods for treating tissues. September 26, 2000: US06123703 (237 worldwide citation)

An ablation catheter system for treating tissues or atherosclerotic tissues of a patient having a retractable metallic element means comprising a deployable close loop with a running noose at its end, the ablation catheter providing RF therapy to the tissues through the retractable metallic elements ...


46
Ira Sanders, Christopher M Shaari: Treatment of autonomic nerve dysfunction with botulinum toxin. Mount Sinai School of Medicine of the City University of New York, Baker & Botts, June 16, 1998: US05766605 (235 worldwide citation)

There is disclosed according to the present invention a method for the control of autonomic nerve function in a mammal comprising administering a therapeutically effective amount of botulinum toxin to the mammal. Preferred embodiments include administering the toxin to control the function of an aut ...


47
Shlomo Gabbay, Robert Frater: Suture organizer, prosthetic device holder, and related surgical procedures. Albert Einstein College of Medicine of Yeshiva University, Stephen E Feldman, Marvin Feldman, January 29, 1980: US04185636 (234 worldwide citation)

A plurality of organizers each formed with an arcuate support member upon which a selected number of suture holding devices are positioned in spaced relationship one to the other, are each designed to be disposed proximate an area of a body upon which surgery is to be performed to faciliate speedy a ...


48
Arthur E Colvin Jr: Optical-based sensing devices, especially for in-situ sensing in humans. Sensors for Medicine and Science, Rothwell Figg Ernst & Manbeck, October 16, 2001: US06304766 (232 worldwide citation)

An optical-based sensor for detecting the presence or amount of an analyte. The sensor has a sensor body which functions as a wave guide, with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator molecules on the surface of the body. At least one optical c ...


49
Jim Haralambidis: Nucleoside derivatives. Howard Florey Institute of Experimental Physiology and Medicine, Sughrue Mion Zinn Macpeak & Seas, September 3, 1996: US05552540 (230 worldwide citation)

A nucleoside derivative of formula (1), characterized in that: Y is H or OH or a protected hydroxy group; X is H, a phosphonate group or a phosphoramidite group of formula (II), where R.sup.1 and R.sup.2 are the same or different, and are selected from alkyl and substituted alkyl, which may be branc ...


50
Jeffery C Lesho: Implanted sensor processing system and method for processing implanted sensor output. Sensors for Medicine and Science, Rothwell Figg Ernst & Manbeck, June 4, 2002: US06400974 (230 worldwide citation)

A quantitative measurement system includes an external unit and an internal unit are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit would be implanted either subcutaneously or otherwise within the b ...



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