41
Patricia A Broderick: Cathodic electrochemical current arrangement with telemetric application. Research Foundation The City University of New York, Morgan & Finnegan, November 28, 1989: US04883057 (240 worldwide citation)

This invention relates to a method for producing a cathodic, or reduction, current used in an in vivo semidifferential, semiderivative and/or semiintegral electrochemical method for achieving routine, reliable, and reproducible measurements of the dynamics of neurochemicals and neurochemical-like ma ...


42
Ralph S Greco, Richard A Harvey, Stanley Z Trooskin: Drug bonded prosthesis and process for producing same. University of Medicine and Dentistry of New Jersey, Klauber & Jackson, November 7, 1989: US04879135 (239 worldwide citation)

There is disclosed an improved prosthesis coated, respectively, with an anionic surfactant, a drug such as an antibiotic and/or antithrombotic agent. Optionally, the coated prosthesis may be treated with an ion exchange compound, to remove un-drug bound anionic surfactant. The drug is bound directly ...


43
Lisa B Shih, Frederick J Primus, Milton D Goldenberg: Tumoricidal methotrexate-antibody conjugate. Center for Molecular Medicine & Immunology, Bernhard D Saxe, October 13, 1987: US04699784 (235 worldwide citation)

A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.


44
James A Woodard Jr, Charles J Scheib, Chad P Boudreaux, Dean B Bruewer, Richard F Schwemberger, Christopher J Schall, Jerome R Morgan, Robert J Simms, Douglas J Siebenaler, Jeffrey S Swayze, John N Ouwerkerk: Fastener system comprising a retention matrix. Ethicon Endo Surgery, September 10, 2013: US08529600 (234 worldwide citation)

A surgical fastener system can comprise a plurality of fasteners which can be connected to one another by a retention matrix which is assembled to the fasteners in order to capture tissue therebetween. In various embodiments, each fastener can comprise a base and the distance in which the retention ...


45
Shlomo Gabbay, Robert Frater: Suture organizer, prosthetic device holder, and related surgical procedures. Albert Einstein College of Medicine of Yeshiva University, Stephen E Feldman, Marvin Feldman, January 29, 1980: US04185636 (233 worldwide citation)

A plurality of organizers each formed with an arcuate support member upon which a selected number of suture holding devices are positioned in spaced relationship one to the other, are each designed to be disposed proximate an area of a body upon which surgery is to be performed to faciliate speedy a ...


46
Ira Sanders, Christopher M Shaari: Treatment of autonomic nerve dysfunction with botulinum toxin. Mount Sinai School of Medicine of the City University of New York, Baker & Botts, June 16, 1998: US05766605 (233 worldwide citation)

There is disclosed according to the present invention a method for the control of autonomic nerve function in a mammal comprising administering a therapeutically effective amount of botulinum toxin to the mammal. Preferred embodiments include administering the toxin to control the function of an aut ...


47
Lily Chen Tu, Hosheng Tu: Ablation catheter and methods for treating tissues. September 26, 2000: US06123703 (231 worldwide citation)

An ablation catheter system for treating tissues or atherosclerotic tissues of a patient having a retractable metallic element means comprising a deployable close loop with a running noose at its end, the ablation catheter providing RF therapy to the tissues through the retractable metallic elements ...


48
Swaminathan Jayaraman: Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use. Iowa India Investments Company of Douglas, Pennie & Edmonds, May 2, 2000: US06056722 (225 worldwide citation)

The present invention preferably includes a balloon catheter for use with a guidewire. The catheter has a body with a balloon located thereon, preferably at the distal end. A lumen within the catheter body communicates with the interior of the balloon which can be inflated by known methods with sali ...


49
James S Burns, Daniel R Marshak: Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means. Armstrong Pharmaceuticals, Whitham & Marhoefer, February 8, 1994: US05284133 (225 worldwide citation)

An inhalation device is provided with a mechanism to assure patient compliance with a drug dosage regimen. The control mechanism includes a controller (24), a timer (26), an actuator (28) and a signalling device (30). The controller (24) is programmed or preset with a time and dosage schedule for th ...


50
Arthur E Colvin Jr: Optical-based sensing devices, especially for in-situ sensing in humans. Sensors for Medicine and Science, Rothwell Figg Ernst & Manbeck, October 16, 2001: US06304766 (223 worldwide citation)

An optical-based sensor for detecting the presence or amount of an analyte. The sensor has a sensor body which functions as a wave guide, with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator molecules on the surface of the body. At least one optical c ...



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