41
Ergin Atalar, Paul A Bottomley, Elias Zerhouin, Henry Halperin, Elliot McVeigh, Albert C Lardo: Methods for in vivo magnetic resonance imaging. Johns Hopkins Unversity School of Medicine, Foley Hoag, April 15, 2003: US06549800 (235 worldwide citation)

The systems and methods of the present invention provide for MRI probes adapted for insertion into a plurality of body orifices, in order to evaluate the anatomy of proximate anatomic structures, to diagnose abnormalities thereof and to treat the diagnosed abnormalities. MRI probes are described tha ...


42
Daniel P Kuban, H Lee Martin, Steven D Zimmermann: Omniview motionless camera endoscopy system. TeleRobotics International, Pitts & Brittian, May 17, 1994: US05313306 (234 worldwide citation)

A endoscopic-type device for omnidirectional image viewing providing electronic pan-and-tilt orientation, rotation, and magnification within a selected field-of-view for use in applications in various environments such as in internal medicine inspection, monitoring, and surgery. The imaging device ( ...


43
Ira Sanders, Christopher M Shaari: Treatment of autonomic nerve dysfunction with botulinum toxin. Mount Sinai School of Medicine of the City University of New York, Baker & Botts, June 16, 1998: US05766605 (233 worldwide citation)

There is disclosed according to the present invention a method for the control of autonomic nerve function in a mammal comprising administering a therapeutically effective amount of botulinum toxin to the mammal. Preferred embodiments include administering the toxin to control the function of an aut ...


44
James A Woodard Jr, Charles J Scheib, Chad P Boudreaux, Dean B Bruewer, Richard F Schwemberger, Christopher J Schall, Jerome R Morgan, Robert J Simms, Douglas J Siebenaler, Jeffrey S Swayze, John N Ouwerkerk: Fastener system comprising a retention matrix. Ethicon Endo Surgery, September 10, 2013: US08529600 (231 worldwide citation)

A surgical fastener system can comprise a plurality of fasteners which can be connected to one another by a retention matrix which is assembled to the fasteners in order to capture tissue therebetween. In various embodiments, each fastener can comprise a base and the distance in which the retention ...


45
Shlomo Gabbay, Robert Frater: Suture organizer, prosthetic device holder, and related surgical procedures. Albert Einstein College of Medicine of Yeshiva University, Stephen E Feldman, Marvin Feldman, January 29, 1980: US04185636 (231 worldwide citation)

A plurality of organizers each formed with an arcuate support member upon which a selected number of suture holding devices are positioned in spaced relationship one to the other, are each designed to be disposed proximate an area of a body upon which surgery is to be performed to faciliate speedy a ...


46
Lisa B Shih, Frederick J Primus, Milton D Goldenberg: Tumoricidal methotrexate-antibody conjugate. Center for Molecular Medicine & Immunology, Bernhard D Saxe, October 13, 1987: US04699784 (229 worldwide citation)

A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.


47
James S Burns, Daniel R Marshak: Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means. Armstrong Pharmaceuticals, Whitham & Marhoefer, February 8, 1994: US05284133 (225 worldwide citation)

An inhalation device is provided with a mechanism to assure patient compliance with a drug dosage regimen. The control mechanism includes a controller (24), a timer (26), an actuator (28) and a signalling device (30). The controller (24) is programmed or preset with a time and dosage schedule for th ...


48
Swaminathan Jayaraman: Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use. Iowa India Investments Company of Douglas, Pennie & Edmonds, May 2, 2000: US06056722 (224 worldwide citation)

The present invention preferably includes a balloon catheter for use with a guidewire. The catheter has a body with a balloon located thereon, preferably at the distal end. A lumen within the catheter body communicates with the interior of the balloon which can be inflated by known methods with sali ...


49
Lily Chen Tu, Hosheng Tu: Ablation catheter and methods for treating tissues. September 26, 2000: US06123703 (223 worldwide citation)

An ablation catheter system for treating tissues or atherosclerotic tissues of a patient having a retractable metallic element means comprising a deployable close loop with a running noose at its end, the ablation catheter providing RF therapy to the tissues through the retractable metallic elements ...


50
Arthur E Colvin Jr: Optical-based sensing devices, especially for in-situ sensing in humans. Sensors for Medicine and Science, Rothwell Figg Ernst & Manbeck, October 16, 2001: US06304766 (222 worldwide citation)

An optical-based sensor for detecting the presence or amount of an analyte. The sensor has a sensor body which functions as a wave guide, with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator molecules on the surface of the body. At least one optical c ...



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