1
Djuric Stevan Wakefield, Docter Stephen Hermann, Yu Stella Siu Tzyy: Leukotriene b¿4? antagonists. Gd Searle & Co, Djuric Stevan Wakefield, Docter Stephen Hermann, Yu Stella Siu Tzyy, sWILLIAMS Roger A, January 9, 1992: WO/1992/000011 (11 worldwide citation)

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R?1¿ is alkyl; R?2¿ is hydrogen or alkyl; R?6¿ is alkyl; n is 1 to 5; p is 0 to 6; x is 0 or 2; and R?4¿ and R?5¿ are inde ...


2
Cohen Noal, Daniewski Andrzej Robert, Lee Ferdinand Kwo Chen, Yagaloff Keith Alan: Bicyclic carboxylic acid leukotriene b¿4? antagonists. F Hoffmann La Roche, Cohen Noal, Daniewski Andrzej Robert, Lee Ferdinand Kwo Chen, Yagaloff Keith Alan, POPPE Regina, June 15, 1995: WO/1995/015956

The invention relates to a compound of formulae: wherein R?2¿, each occurence, independently, is hydroxy, lower alkoxy or NR?3¿R?4¿, wherein R?3¿ and R?4¿, independently, are hydrogen or lower alkyl, and Ph is phenyl and, for the compound of formula C, its geometric isomer, and, when R?2¿ is hydroxy ...


3
Cohen Noal, Lee Ferdinand Kwo Chen, Yagaloff Keith Alan: Substituted pyridine leukotriene b¿4? antagonists. F Hoffmann La Roche, Cohen Noal, Lee Ferdinand Kwo Chen, Yagaloff Keith Alan, POPPE Regina, October 26, 1995: WO/1995/028386

Compounds of formula (I), wherein X is O or C=O; Y is CN, S(O)¿u?R?8¿, NR?5¿SO¿2?R?8¿, OR?9¿, R?10¿ or -C¿6?H¿4?R?10¿; Z is -(O)¿y?-(CR?5¿R?6¿)¿s?-R?10¿, -(O)¿y?-(CR?5¿R?6¿)¿v?-OR?9¿ or R?10¿; R?1¿, R?3¿ are, independently, aryl, substituted aryl, heteroaryl, lower alkyl or aralkyl; R?2¿ is hydrogen ...


4
Koch Kevin, Melvin Lawrence S Jr, Reiter Lawrence A, Ruggeri Sally G: Benzopyran and related ltb¿4? antagonists. Pfizer, Koch Kevin, Melvin Lawrence S Jr, Reiter Lawrence A, Ruggeri Sally G, RICHARDSON Peter C, August 5, 1993: WO/1993/015066

Benzopyran and other benzo-fused leukotriene B¿4? antagonists have formula (I) wherein A, n, R?1¿, R?2¿ and R?3¿ are as defined herein. The compounds of formula (I) wherein R?1¿ is c-substituted CR?4¿R?5¿-COOR?13¿ may be prepared from the corresponding c-substituted CF¿3?SO¿3? compound by reaction w ...


5
Koch Kevin: Benzopyran and related ltb¿4? antagonists. Pfizer, Koch Kevin, RICHARDSON Peter C, August 5, 1993: WO/1993/015067

Benzopyran and other benzo-fused leukotriene B¿4? antagonists have formula (I) wherein R?1¿ is a phenyl or substituted phenyl group, and A, n, R?2¿ and R?3¿ are as defined herein.


6
Djuric Stevan Wakefield, Yu Stella Siu Tzyy: Leukotriene b¿4? antagonists. Gd Searle & Co, Djuric Stevan Wakefield, Yu Stella Siu Tzyy, sFEDER Scott B, December 14, 1995: WO/1995/033742

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R?1¿ is alkyl; R?2¿ represents alkyl from 1 to 5 carbon atoms, aryl or aryl substituted with halogen or alkyl from 1 to 5 ...


7
Djuric Stevan Wakefield, Penning Thomas Dale: Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists. Gd Searle & Co, Djuric Stevan Wakefield, Penning Thomas Dale, sFEDER Scott B, November 30, 1995: WO/1995/032201

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R represents alkyl having 2 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, alkynyl having 2 to 6 carbon atoms, or -(CH¿2?)¿m?-R?3¿ wherein R?3¿ represents cycloalky ...


8
Djuric Stevan Wakefield, Penning Thomas Dale: Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof. Gd Searle & Co, Djuric Stevan Wakefield, Penning Thomas Dale, sWILLIAMS Roger A, November 28, 1991: WO/1991/017989

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl and m is 1 or 2; R?1¿ is alkyl of 1 to 4 carbon atoms; R?2¿ is hydrogen or alkyl of 1 to 5 carbon atoms; R?4¿ is alkyl of 1 ...


9
Heindl Josef, Skuballa Werner, Buchmann Bernd, Fröhlich Wolfgang, Ekerdt Roland, Giesen Claudia: (De) Neue leukotrien-b¿4?-antagonisten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, (En) New leukotriene-b¿4? antagonists, process for producing the same and their use as medicinal drugs. Schering Aktiengesellschaft Berlin Und Bergkamen, Heindl Josef, Skuballa Werner, Buchmann Bernd, Fröhlich Wolfgang, Ekerdt Roland, Giesen Claudia, March 19, 1992: WO/1992/004311

(EN) Leukotriene-B¿4? antagonists have formula (I), in which X represents a CH¿2? group or an oxygen atom; Y is C¿1?-C¿4?-alkoxy or -S(O)¿p?-(C¿1?-C¿4?)-alkyl; p is 0, 1 or 2; Z can represent a hydrogen atom or the residue A-B-COOH, where A represents a hydroxymethylene group or a carbonyl group and ...


10
Djuric Stevan Wakefield, Penning Thomas Dale, Snyder James Patrick: Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof. Gd Searle & Co, Djuric Stevan Wakefield, Penning Thomas Dale, Snyder James Patrick, sWILLIAMS Roger A, November 14, 1991: WO/1991/017160

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or (CH¿2?)¿m? R?3¿ where R?3¿ is cycloalkyl and m is 1 or 2; R?1¿ is alkyl; R?2¿ is hydrogen or alkyl; R?4¿ is alkyl; n is an interger from 1 ...