31
John Rhodes, Brian Kenneth Evans: Composition for treatment of constipation and irritable bowel syndrome. John Rhodes, Brian Kenneth Evans, Birch Stewart Kolasch & Birch, May 11, 2004: US06734188 (37 worldwide citation)

Constipation and Irritable Bowel Syndrome are treated by a delayed and sustained release composition of an opioid antagonist which commences release of the opioid antagonist in the mid to distal small intestine or ascending colon and provides sustained release along any remaining part of the small i ...


32
Samuel K Yue: Method of treating myofascial pain syndrome with relaxin. January 26, 1999: US05863552 (37 worldwide citation)

A method of treating involuntary muscle dysfunctions includes administering a therapeuticaly effective amount of relaxin to a patient. Involuntary muscle dysfunctions amenable to treatment with relaxin include fibromyalgia, myofascial pain syndrome, chronic fatigue syndrome, dystonia, pelvic floor d ...


33
Ernst Glen, Phillips Eifion, Schmiesing Richard: Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists.. Astrazeneca, Ernst Glen, Phillips Eifion, Schmiesing Richard, ASTRAZENECA, February 26, 2004: WO/2004/016616 (37 worldwide citation)

Nicotinic acetylcholine receptor agonists of formula I wherein a, b, c, D and R are as defined in the specification, enantiomers, pharmaceutically- acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same in the treatment or prophylaxis of psychotic ...


34
Henry C Lin, Mark Pimentel: Methods of treating diarrhea caused by small intestinal bacterial overgrowth. Cedars Sinai Medical Center, Seth D Levy, Davis Wright Tremaine, May 3, 2011: US07935799 (36 worldwide citation)

Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of s ...


35
Stephen C Perry: Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome. Malin Haley & DiMaggio P A, March 20, 2001: US06203797 (36 worldwide citation)

A dietary supplement for use as a probiotic and for alleviating symptoms of irritable bowel syndrome, comprising freeze-dried aloe, fructo-oligosaccharides, and dahlia inulin juice mixture and optionally vitamin B6 (pyridoxine) manganese and L-glutamine. An additional alternate embodiments specifica ...


36
Iguchi Satoru, Katsu Yasuhiro, Sone Hiroki, Uchida Chikara, Kojima Takashi: Benzimidazolone compounds having 5-ht4 receptor agonistic activity. Pfizer Japan, Pfizer, Iguchi Satoru, Katsu Yasuhiro, Sone Hiroki, Uchida Chikara, Kojima Takashi, FULLER Grover F Jr, March 10, 2005: WO/2005/021539 (36 worldwide citation)

This invention provides a compound of the formula (I) or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, no ...


37
Peter E Cross, Alexander R MacKenzie: Pyrrolidine derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Seymore G Bekelnitzky, March 17, 1992: US05096890 (35 worldwide citation)

Compounds of the formula ##STR1## wherein R, Y and R.sup.1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altere ...


38
Per Hellström, Suad Efendic: Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein. McDermott Will & Emery, February 19, 2002: US06348447 (34 worldwide citation)

The invention relates to the new use of gastrointestinal peptide hormones selected from the class consisting of glucagon-like peptide-1 (GLP-1) and derivatives thereof having anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract for the manufacture of a pharmac ...


39
Samuel K Yue: Method of treating fibromyalgia with relaxin. Kinney & Lange P A, January 13, 1998: US05707642 (34 worldwide citation)

A method of treating involuntary muscle dysfunctions includes administering a therapeuticaly effective amount of relaxin to a patient. Involuntary muscle dysfunctions amenable to treatment with relaxin include fibromyalgia, myofascial pain syndrome, chronic fatigue syndrome, dystonia, pelvic floor d ...


40
Daniel P Becker, Daniel L Flynn, Alan E Moormann, Roger Nosal, Clara I Villamil: Imidazopyridines as serotonergic 5-HT.sub.3 antagonists. G D Searle & Co, Cynthia S Kovacevic, Roger A Williams, November 9, 1993: US05260303 (33 worldwide citation)

The imidazopyridines compounds of the present invention are serotonergic 5-HT.sub.3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses ...