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Paul Edward Aldrich, Argyrios Georgios Arvanitis, Rajagopal Bakthavatchalam, James Peter Beck, Robert Scott Cheeseman, Robert John Chorvat, Paul Joseph Gilligan, Carl Nicholas Hodge, Zelda Rakowitz Wasserman: 1N-alkyl-N-arylpyrimidinamines and derivatives thereof. Dupont Pharmaceuticals Company, Monte R Browder, Kenneth B Rubin, August 22, 2000: US06107301 (58 worldwide citation)

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppressi ...


12
Dimarchi Richard Dennis, Glaesner Wolfgang, Millican Rohn Lee Junior, Vick Andrew Mark, Zhang Lianshan: Polyethelene glycol link glp-1 compounds. Eli Lilly And Company, Dimarchi Richard Dennis, Glaesner Wolfgang, Millican Rohn Lee Junior, Vick Andrew Mark, Zhang Lianshan, COX Gregory, November 4, 2004: WO/2004/093823 (57 worldwide citation)

The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositio ...


13
Bernard Hulin, Janice C Parker: Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, March 23, 2004: US06710040 (53 worldwide citation)

The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with proteins that are subject to processing by DPP-IV, suc ...


14
Henry C Lin, Mark Pimentel: METHOD OF DIAGNOSING IRRITABLE BOWEL SYNDROME AND OTHER DISORDERS CAUSED BY SMALL INTESTINAL BACTERIAL OVERGROWTH BY DETECTING THE PRESENCE OF ANTI-SACCHAROMYCES CERIVISIAE ANTIBODIES (ASCA) IN HUMAN SERUM. Cedars Sinai Medical Center, Sidley Austin Brown & Wood, May 13, 2003: US06562629 (53 worldwide citation)

Disclosed is a method of diagnosing small intestinal bacterial overgrowth (SIBO), irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder (ADHD), or an autoimmune disease by sampling serum from a human subject having a suspected diagnosi ...


15
Henry C Lin, Mark Pimentel: Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions. Cedars Sinai Medical Center, Seth D Levy, Davis Wright Tremaine, May 23, 2006: US07048906 (48 worldwide citation)

Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory ...


16
Theoharis C Theoharides: Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin. KOS Pharmaceutical, July 15, 1997: US05648355 (47 worldwide citation)

A method for treating endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin, such as abdominal migraine and irritable bowel syndrome, entails administering a pharmacologically effective amount of a mast cell degranulation-blocking agent.


17
Ernesto Marcelo Dario Korenman, Tuvi Orbach, Bernard William Watson: Biofeedback apparatus for use in therapy. Ultramind International, Breiner & Breiner, February 15, 2000: US06026322 (45 worldwide citation)

Apparatus and a program designed to train the user to control one or more aspects of his or her psycho-physiological state is controlled by signals representative of a psycho-physiological parameter of the user, e.g. galvanic skin resistance. This may be detected by a sensor unit with two contacts o ...


18
Charles E Day: Method for treatment of irritable bowel syndrome. Gordon W Hueschen, January 10, 1995: US05380522 (44 worldwide citation)

A method of treating irritable bowel syndrome, including diarrhea, constipation, and pain aspects thereof, in a human patient, whereby the method involves the step of orally administering to the human patient an amount of an anion-binding polymer and a hydrophilic polymer, either simultaneously, con ...


19
Mase Toshiaki, Mitsuya Morihiro, Kobayashi Kensuke, Noguchi Kazuhito: Substituted heteroaromatic derivatives. Banyu Pharma, September 9, 1998: EP0863141-A1 (44 worldwide citation)

This invention provides substituted heteroaromatic ring derivatives which are represented by a general formula ÄIÜ below: Äin the formula, R and R may be same or different and each signifies hydrogen, halogen or lower alkyl; R signifies C3-C6 cycloalkyl or cycloalkenyl; R signifies a heteroaromatic ...


20
Thomas Julius Borody, Walter George Shortis, Nicolas Peter Shortis: Picosulfate-containing preparation for colonic evacuation. January 12, 1999: US05858403 (41 worldwide citation)

An osmotic colonic evacuant in solid dosage form, which comprises a phosphate based laxative or a sulfate based laxative and preferably comprises sodium picosulfate and an antacid, is used preferably in conjunction with 250 ml to 1,500 ml diluent, alone or as part of a sequential pack, to evacuate t ...



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