1
Alexander James Bridges: Irreversible inhibitors of tyrosine kinases. Warner Lambert Company, Charles W Ashbrook, October 3, 2000: US06127374 (60 worldwide citation)

This invention provides irreversible inhibitors of tyrosine kinases having for formula ##STR1## which compounds are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis.


2
Alexander James Bridges, William Alexander Denny, Ellen Myra Dobrusin, Annette Marian Doherty, David William Fry, Dennis Joseph McNamara, Howard Daniel Hollis Showalter, Jeffrey B Smaill, Hairong Zhou: Irreversible inhibitors of tyrosine kinases. Warner Lambert Company, Todd M Crissey, Linda A Vag, Suzanne M Harvey, February 5, 2002: US06344459 (52 worldwide citation)

The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyros ...


3
Alexander James Bridges: Irreversible bicyclic inhibitors of tyrosine kinases. Warner Lambert Company, Francis J Tinney, November 28, 2000: US06153617 (47 worldwide citation)

The invention provides compounds of Formula I ##STR1## that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhi ...


4
Alexander James Bridges: Irreversible inhibitors of tyrosine kinases. Warner Lambert Company, Charles W Ashbrook, Rosanne Goodman, May 13, 2003: US06562818 (40 worldwide citation)

The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyros ...


5
Alexander James Bridges, William Alexander Denny, Ellen Myra Dobrusin, Annette Marian Doherty, David William Fry, Dennis Joseph McNamara, Howard Daniel Hollis Showalter, Jeffrey B Smaill, Hairong Zhou: Irreversible inhibitors of tyrosine kinases. Warner Lambert Company, Linda A Vag, Suzanne M Harvey, Rosanne Goodman, August 5, 2003: US06602863 (27 worldwide citation)

The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyros ...


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Alexander James Bridges, William Alexander Denny, Ellen Myra Dobrusin, Annette Marian Doherty, David William Fry, Dennis Joseph McNamara, Howard Daniel Hollis Showalter, Jeffrey B Smaill, Hairong Zhou: Pyrimido[5,4-d]pyrimidines derivatives as irreversible inhibitors of tyrosine kinases. Warner Lambert Company, Jeffrey H Tidwell, Stephen D Prodnuk, Suzanne M Bates, August 31, 2010: US07786131 (2 worldwide citation)

The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the tr ...


8
Brian L Hodous, Lesley Liu Bujalski, Reinaldo Jones, Donald Bankston, Theresa L Johnson, Igor Mochalkin, Ngan Nguyen, Hui Qiu, Andreas Goutopoulos, Nadia Brugger: Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity. Merck Patent, Dwight D Kim, EMD Serono Research and Development Institute, February 28, 2017: US09580449

The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjog ...


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Bridges Alexander James, Denny William Alexander, Dobrusin Ellen Myra, Doherty Annette Marian, Fry David W, Mcnamara Dennis Joseph, Showalter Howard Daniel Hollis, Smaill Jeffrey B, Zhou Hairong: Inhibiteurs irreversibles de tyrosine kinases, Irreversible inhibitors of tyrosine kinases. Warner Lambert Company, Warner Lambert Company, MACRAE & CO, October 23, 1997: CA2249446

The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyros ...