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Donna L Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C Harriman, Alan Franklin Corin, Craig E Masse, Mee Shelley: IRAK inhibitors and uses thereof. Nimbus Iris, Choate Hall & Stewart, Andrea C Robidoux, Thomas H McLean, April 22, 2014: US08703941 (8 worldwide citation)

The present invention provides thienopyrimidine and thienopyridine compounds, compositions thereof, and methods of using the same for the treatment of diseases mediated by IRAK enzymes. Such diseases include inflammatory and proliferative diseases.


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ROMERO Donna L, WESSEL Matthew David, ROBINSON Shaughnessy, GREENWOOD Jeremy Robert, WATTS Karl Shawn, FRYE Leah Lynn, HARRIMAN Geraldine C, CORIN Alan Franklin, MASSE Craig: INHIBITEURS DIRAK ET LEURS UTILISATION, IRAK INHIBITORS AND USES THEREOF. NIMBUS IRIS, ROMERO Donna L, WESSEL Matthew David, ROBINSON Shaughnessy, GREENWOOD Jeremy Robert, WATTS Karl Shawn, FRYE Leah Lynn, HARRIMAN Geraldine C, CORIN Alan Franklin, MASSE Craig, ROBIDOUX Andrea L C, July 19, 2012: WO/2012/097013 (5 worldwide citation)

The present invention relates to compounds and methods useful for inhibiting one or more interleukin-l receptor-associated kinases ("IRAK"). In some embodiments, a provided compound inhibits IRAK-1 and IRAK-4. The invention also provides pharmaceutically acceptable compositions comprising compounds ...


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Donna L Romero, Shaughnessy Robinson, Matthew David Wessel, Jeremy Robert Greenwood: IRAK inhibitors and uses thereof. Nimbus Iris, Choate Hall & Stewart, Andrea L C Reid, Thomas H McLean, July 21, 2015: US09085586 (2 worldwide citation)

The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.


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HARRIMAN Geraldine C, WESTER Ronald T, ROMERO Donna L, ROBINSON Shaughnessy, SHELLEY Mee, WESSEL Matthew David, GREENWOOD Jeremy Robert, MASSE Craig E, KAPELLER LIBERMANN Rosana: [fr] INHIBITEURS DIRAK ET LEURS UTILISATIONS, [en] IRAK INHIBITORS AND USES THEREOF. NIMBUS IRIS, MCLEAN Thomas H, July 18, 2013: WO/2013/106535 (2 worldwide citation)

[en] The present invention provides thieno[2,3-d]pyrimidine derivative compounds, and pharmaceutical compositions thereof. The invention also includes methods inhibiting an IRAK protein kinase in a patient by administering the thieno[2,3-d]pyrimidine derivative compound. The invention also includes ...


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Donna L Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C Harriman, Alan Franklin Corin, Craig E Masse, Mee Shelley: IRAK inhibitors and uses thereof. NIMBUS IRIS, Dechert, Andrea L C Reid, May 17, 2016: US09340554 (1 worldwide citation)

The present invention provides 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine compounds and pharmaceutical compositions thereof as inhibitors of IRAK.


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Donna Romero, Craig E Masse, Shaughnessy Robinson, Jeremy Robert Greenwood, Geraldine C Harriman: IRAK inhibitors and uses thereof. Nimbus Iris, Andrea L C Reid, Dechert, December 13, 2016: US09518065

The present invention provides compounds of the general formula I: or a pharmaceutically acceptable salt thereof, wherein each variable is as defined and described herein, as inhibitors of one or more interleukin-1 receptor-associated kinases (“IRAK”).


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Donna L Romero, Shaughnessy Robinson, Matthew David Wessel, Jeremy Robert Greenwood: IRAK inhibitors and uses thereof. Nimbus Iris, Andrea L C Reid, Dechert, November 1, 2016: US09481687

The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.