1
Carl W Gilbert, Myung Ok Cho: Interferon polymer conjugates. Enzon, Roberts & Mercanti, January 27, 1998: US05711944 (128 worldwide citation)

A process is disclosed for preparing long-acting alpha interferon-containing compositions. Alpha interferon is contacted with a relatively small molar excess of a substantially non-antigenic polymer in the presence of a surfactant to preserve bioactivity. Isolation of the desired conjugate species h ...


2
Richard B Greenwald, Carl W Gilbert: Interferon polymer conjugates and process for preparing the same. Enzon, Roberts & Mercanti L, April 14, 1998: US05738846 (126 worldwide citation)

Interferon-polymer conjugate containing compositions having high levels of retained interferon activity and relatively long circulating lives in vivo are disclosed. The compositions contain a mixture of mono-interferon-polymer conjugates and bis-interferon-polymer conjugates, with both species conta ...


3
Carl W Gilbert, Myung ok Park Cho: Interferon polymer conjugates. Enzon, Roberts & Mercanti, September 14, 1999: US05951974 (61 worldwide citation)

Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for prep ...


4
Carl W Gilbert, Myung ok Park Cho: Interferon polymer conjugates. Enzon, Roberts & Mercanti, March 28, 2000: US06042822 (55 worldwide citation)

Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for prep ...


5
Richard B Greenwald, Carl W Gilbert: .alpha.-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same. Enzon, Roberts & Mercanti, November 9, 1999: US05981709 (46 worldwide citation)

A process for preparing .alpha.-interferon-polymer conjugates having high levels of retained interferon activity and relatively long circulating lives in vivo is disclosed. The process includes forming substantially non-antigenic .alpha.-interferon-polymer conjugates, combining the .alpha.-interfero ...


6
Gilbert Carl W, Cho Myung Ok: Improved interferon polymer conjugates. Enzon, September 11, 1996: EP0730470-A1 (1 worldwide citation)

A process is disclosed for preparing long-acting alpha interferon-containing compositions. Alpha interferon is contacted with a relatively small molar excess of a substantially non-antigenic polymer in the presence of a surfactant to preserve bioactivity. Isolation of the desired conjugate species h ...


7
Gilbert Carl W, Park Cho Myung Ok: Improved interferon polymer conjugates. Schering, October 4, 2000: EP1039922-A1

Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30 % of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for pre ...


8
Greenwald Richard B, Gilbert Carl W: Alpha-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same. Enzon, September 27, 2000: EP1037657-A1

A process for preparing alpha -interferon-polymer conjugates having high levels of retained interferon activity and relatively long circulating lives in vivo is disclosed. The process includes forming substantially non-antigenic alpha -interferon-polymer conjugates, combining the alpha -interferon-p ...


9
Ko Chung Lin, Rudolf Widmann: Therapeutic use of interferon-polymer conjugates. PharmaEssentia, Cesari and McKenna, December 31, 2013: US08617532

This invention relates to use protein-polymer conjugates described in the specification to treat various diseases, including disease is idiopaic myelofibrsis, polycythaemia vera, and essential thromobocythaemia.


10
Greenwald Richard B, Gilbert Carl W: Interferon-polymer conjugates and process for preparing the same. Enzon, September 9, 1998: EP0862455-A1

Interferon-polymer conjugate containing compositions having high levels of retained interferon activity and relatively long circulating lives in vivo are disclosed. The compositions contain a mixture of mono-interferon-polymer conjugates and bis-interferon-polymer conjugates, with both species conta ...