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LIANG Peng, MITSUYA Morihiro, OGINO Yoshio, QI Changhe, TAKAHASHI Hidekazu, TEMPEST Paul, WANG Jiabing, WANG Zhenzhen, ZHANG Shaohua, ZHOU Nanyan, ZHU Jiuxiang: Inhibiteurs de lactivité dakt, Inhibitors of akt activity. Merck Sharp & Dohme, Banyu Pharmaceutical, LIANG Peng, MITSUYA Morihiro, OGINO Yoshio, QI Changhe, TAKAHASHI Hidekazu, TEMPEST Paul, WANG Jiabing, WANG Zhenzhen, ZHANG Shaohua, ZHOU Nanyan, ZHU Jiuxiang, Liu Shen & Associates, October 27, 2011: WO/2011/130921

The instant invention provides for substituted thiazoles that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by a ...



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