61
Webb Steven Robert, Henry Matthew J: Vaccine for avian influenza and methods of use. Dow Agrosciences, Webb Steven Robert, Henry Matthew J, EISENSCHENK Frank C, May 22, 2008: WO/2008/060669 (3 worldwide citation)

The subject invention pertains to influenza vaccines and particularly avian influenza vaccines (AIV). The invention includes methods for preparing transgenic plant cells to express know HAl polypeptides having specified homologies that are used to prepare vaccine compositions and methods for inducin ...


62
GALARZA JOSE: Universal virus-like particle (vlp) influenza vaccines. TECHNOVAX, Pasternak Dahna S, August 25, 2011: WO/2011/102900 (3 worldwide citation)

Described herein are influenza virus-like particles (VLPs) that display one or more truncated, re-engineered or remodeled HA molecules on their surface. Also described are methods of making and using these VLPs.


63
Rappuoli Rino, O Hagan Derek, Del, Giudice Giuseppe: Adjuvanted influenza vaccines including cytokine-inducing agents. Novartis Vaccines And Diagnostics, Rappuoli Rino, O Hagan Derek, Del, Giudice Giuseppe, MARSHALL Cameron John, May 10, 2007: WO/2007/052056 (3 worldwide citation)

While oil-in-water emulsions are excellent adjuvants for influenza vaccines, their efficacy can be improved by additionally including other immunostimulating agent(s) to improve cytokine responses, such as ϝ-interferon response. Thus a vaccine comprises: (i) an influenza virus antigen; (ii) a ...


64
Scheffczik Hanno: Storage of influenza vaccines without refrigeration. Novartis Vaccines And Diagnostics & Co Kg, Scheffczik Hanno, MARSHALL Cameron John, October 4, 2007: WO/2007/110776 (3 worldwide citation)

Antigens from individual influenza virus strains are not refrigerated before being combined to make multivalent influenza virus vaccines. Moreover, influenza vaccines are not refrigerated between packaging and administration. Thus the need for refrigeration is minimized, and the cold-chain does not ...


65
Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle: Soluble recombinant influenza antigens. Medicago, Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle, Sechley Konrad A, January 14, 2010: WO/2010/003235 (3 worldwide citation)

The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal ...


66
BAKER David, WHITEHEAD Timothy A, FLEISHMAN Sarel: Polypeptides pour traitement et/ou limitation dinfection par la grippe, Polypeptides for treating and/or limiting influenza infection. University Of Washington Through Its Center For Commercialization, BAKER David, WHITEHEAD Timothy A, FLEISHMAN Sarel, OSLICK Sherri L, February 9, 2012: WO/2012/018907 (3 worldwide citation)

The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolat ...


67
Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble: Multi plasmid system for the production of influenza virus. MedImmune, Grant IP, May 13, 2014: US08722059 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.


68
Ronaldus Adrianus Maria Fouchier, Bernadetta Gerarda Van Den Hoogen, Albertus Dominicus Marcellinus Erasmus Osterhaus, Jan Cornelius De Jong, Jan Groen: Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences. Erasmus University Medical Center Rotterdam, TraskBritt P C, February 14, 2017: US09567653 (2 worldwide citation)

Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumov ...


69
Bin Lu, Hong Jin: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, January 15, 2013: US08354114 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


70
Qi Dang, Richard Schwartz: Methods of producing influenza vaccine compositions. MedImmune, March 31, 2009: US07510719 (2 worldwide citation)

Methods and compositions for the optimization and production of influenza viruses, e.g., ca influenza B strains, in eggs and host cells suitable as influenza vaccines are provided.



Click the thumbnails below to visualize the patent trend.