61
Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle: Soluble recombinant influenza antigens. Medicago, Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle, Sechley Konrad A, January 14, 2010: WO/2010/003235 (3 worldwide citation)

The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal ...


62
George Kemble, Gregory Duke: Multi plasmids system for the production of influenza virus. Medimmune, Grant Anderson, April 2, 2013: US08409843 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


63
Erich Hoffmann, Hong Jin, George Kemble, Zhongying Chen: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, November 5, 2013: US08574591 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


64
Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble: Multi plasmid system for the production of influenza virus. MedImmune, Grant IP, May 13, 2014: US08722059 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.


65
Maria Grazia Pau, Alphonsus G C M UytdeHaag: Production of vaccines. Crucell Holland, TraskBritt, November 16, 2010: US07833788 (2 worldwide citation)

Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium ...


66
Qi Dang, Richard Schwartz: Methods of producing influenza vaccine compositions. MedImmune, March 31, 2009: US07510719 (2 worldwide citation)

Methods and compositions for the optimization and production of influenza viruses, e.g., ca influenza B strains, in eggs and host cells suitable as influenza vaccines are provided.


67
Erich Hoffmann, Aleksandr S Lipatov, Richard J Webby, Elena A Govorkova, Robert G Webster: Modified influenza virus for monitoring and improving vaccine efficiency. St Jude Children s Research Hospital, Fish & Richardson P C, January 18, 2011: US07871626 (2 worldwide citation)

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by alt ...


68
Jules Maarten Minke, Kemal Karaca, Jiansheng Yao: Canine influenza vaccines. Mevial, Judy Jarecki Black, Mevial, Thomas Kowalski Esq, September 16, 2008: US07425336 (2 worldwide citation)

The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens w ...


69
Influenza vaccines. Sandoz, January 18, 1978: GB1498261-A (2 worldwide citation)

1498261 Influenza vaccines SANDOZ Ltd 13 Jan 1975 [14 Jan 1974] 1290/75 Heading A5B The haemagglutinin and neuramuridase components are isolated from influenza virus by treating the virus in an aqueous medium with a cationic detergent to selectively solubilise such components, and separating the res ...


70
Adamowicz Philippe, Muller Ludwig: Procede pour obtenir des sous-unites virales enrobees de lipide, notamment des antigenes utilises dans des vaccins, produit ainsi obtenu et applications, Process for obtaining lipid envelope virus subunits, notably antigens for use as vaccines, the products obtained and their applications. Institut Pasteur, GOWLING LAFLEUR HENDERSON, December 20, 1983: CA1158978 (2 worldwide citation)

ABSTRACT OF DISCLOSURE The invention relates to a process for producing virus subunits with lipid envelopes. The process consists using a neutral or basic pH: (1)in dissolving a lower halogenated hydrocarbon, at a concentration equivalent to or approximating its limit of solubility, in an aqueous vi ...



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