61
Qi Dang, Richard Schwartz: Methods of producing influenza vaccine compositions. MedImmune, March 31, 2009: US07510719 (3 worldwide citation)

Methods and compositions for the optimization and production of influenza viruses, e.g., ca influenza B strains, in eggs and host cells suitable as influenza vaccines are provided.


62
Emmie De Wit, Monique I J Spronken, Ron A M Fouchier, Albert D M E Osterhaus: Rescue of influenza virus. Abbott Biologicals, Finnegan Henderson Farabow Garrett & Dunner L, June 14, 2011: US07959930 (3 worldwide citation)

The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens' eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. The invention provides a nucleic acid compr ...


63
HOFFMAN ERICH, JIN HONG, LU BIN, DUKE GREG, KEMBLE GEORGE WILLIAM: SYSTEME MULTIPLASMIDE DE PRODUCTION DE VIRUS INFLUENZA, MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS. MEDIMMUNE VACCINES, MEDIMMUNE VACCINES, FETHERSTONHAUGH & CO, September 17, 2013: CA2482946 (3 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.


64
Minke Jules Maarten, Karaca Kemal, Yao Jiansheng: Canine influenza vaccines. Merial, Minke Jules Maarten, Karaca Kemal, Yao Jiansheng, JARECKI BLACK PHD JD Judy, March 1, 2007: WO/2007/024947 (3 worldwide citation)

The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens w ...


65
Webb Steven Robert, Henry Matthew J: Vaccine for avian influenza and methods of use. Dow Agrosciences, Webb Steven Robert, Henry Matthew J, EISENSCHENK Frank C, May 22, 2008: WO/2008/060669 (3 worldwide citation)

The subject invention pertains to influenza vaccines and particularly avian influenza vaccines (AIV). The invention includes methods for preparing transgenic plant cells to express know HAl polypeptides having specified homologies that are used to prepare vaccine compositions and methods for inducin ...


66
GALARZA JOSE: Universal virus-like particle (vlp) influenza vaccines. TECHNOVAX, Pasternak Dahna S, August 25, 2011: WO/2011/102900 (3 worldwide citation)

Described herein are influenza virus-like particles (VLPs) that display one or more truncated, re-engineered or remodeled HA molecules on their surface. Also described are methods of making and using these VLPs.


67
Rappuoli Rino, O Hagan Derek, Del, Giudice Giuseppe: Adjuvanted influenza vaccines including cytokine-inducing agents. Novartis Vaccines And Diagnostics, Rappuoli Rino, O Hagan Derek, Del, Giudice Giuseppe, MARSHALL Cameron John, May 10, 2007: WO/2007/052056 (3 worldwide citation)

While oil-in-water emulsions are excellent adjuvants for influenza vaccines, their efficacy can be improved by additionally including other immunostimulating agent(s) to improve cytokine responses, such as ϝ-interferon response. Thus a vaccine comprises: (i) an influenza virus antigen; (ii) a ...


68
Scheffczik Hanno: Storage of influenza vaccines without refrigeration. Novartis Vaccines And Diagnostics & Co Kg, Scheffczik Hanno, MARSHALL Cameron John, October 4, 2007: WO/2007/110776 (3 worldwide citation)

Antigens from individual influenza virus strains are not refrigerated before being combined to make multivalent influenza virus vaccines. Moreover, influenza vaccines are not refrigerated between packaging and administration. Thus the need for refrigeration is minimized, and the cold-chain does not ...


69
BAKER David, WHITEHEAD Timothy A, FLEISHMAN Sarel: Polypeptides pour traitement et/ou limitation dinfection par la grippe, Polypeptides for treating and/or limiting influenza infection. University Of Washington Through Its Center For Commercialization, BAKER David, WHITEHEAD Timothy A, FLEISHMAN Sarel, OSLICK Sherri L, February 9, 2012: WO/2012/018907 (3 worldwide citation)

The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolat ...


70
Adolfo Garcia Sastre, Peter Palese, John Steel, Anice C Lowen: Influenza virus vaccine and uses thereof. Icahn School of Medicine at Mount Sinai, Jones Day, July 18, 2017: US09708373 (2 worldwide citation)

Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.