51
Maria G Pau, Alphonsus G C M UytdeHaag, Govert J Schouten: Production of vaccines. Crucell Holland, TraskBritt, June 21, 2011: US07964198 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...


52
Maria Grazia Pau, Alphonsus G C M UytdeHaag: Production of vaccines. Crucell Holland, TraskBritt, June 23, 2009: US07550284 (4 worldwide citation)

Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium ...


53
Maria G Pau, Alphonsus G C M UytdeHaag, Govert J Schouten: Production of vaccines. Crucell Holland, TraskBritt, April 21, 2009: US07521220 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...


54
Julien Peetermans, Michele Lobmann, Jean Marie Prevost, Emil Vascoboinic: Live influenza type B virus vaccines and preparation thereof. Recherche et Industrie Therapeutiques, Alan D Lourie, William H Edgerton, June 8, 1976: US03962423 (4 worldwide citation)

Attenuated stable influenza type B virus strains are obtained by recombining a vaccinal and previously attenuated influenza type B virus strain with an influenza type B virus isolate having the desired serotype and isolating a recombinant having at least one marker property of the attenuated parent ...


55
Vajdy Michael, O Hagan Derek: Adminstration routes for priming/boosting with influenza vaccines. Novartis Vaccines And Diagnostics, Vajdy Michael, O Hagan Derek, MARSHALL Cameron John, May 10, 2007: WO/2007/052057 (4 worldwide citation)

Patients receive a mucosal influenza vaccine and then receive a parenteral influenza vaccine, in that order, typically during different visits to a vaccination centre.


56
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, LAVOIE PIERRE OLIVIER, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE: PSEUDO-PARTICULES DU VIRUS DE LA GRIPPE (VLP) COMPRENANT DE LHEMAGGLUTININE (HA) PRODUIT DANS UNE PLANTE, INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, September 24, 2013: CA2693956 (4 worldwide citation)

A method for synthesizing influenza virus--like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pr ...


57
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE, LAVOIE PIERRE OLIVIER: PARTICULES PSEUDOVIRALES (VLP) DE LA GRIPPE RECOMBINEES PRODUITES DANS DES PLANTES TRANSGENIQUES EXPRIMANT LHEMAGGLUTININE, RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, November 19, 2013: CA2707235 (4 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


58
Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A: Modified influenza virus for monitoring and improving vaccine efficiency. St Jude Children S Research Hospital, Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A, LUDWIG S Peter, February 15, 2007: WO/2007/019094 (4 worldwide citation)

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by alt ...


59
Couture Manon, Vézina Louis Philippe, Landry Nathalie: New influenza virus immunizing epitope. Medicago, Couture Manon, Vézina Louis Philippe, Landry Nathalie, Ogilvy Renault Sencrl, January 21, 2010: WO/2010/006452 (4 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of a novel influenza HA protein in plants and its purification The invention is also directed towards a VLP comprising influenza HA protein and plants li ...


60
Bin Lu, Hong Jin: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, January 15, 2013: US08354114 (3 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...