51
Julien Peetermans, Michele Lobmann, Jean Marie Prevost, Emil Vascoboinic: Live influenza type B virus vaccines and preparation thereof. Recherche et Industrie Therapeutiques, Alan D Lourie, William H Edgerton, June 8, 1976: US03962423 (4 worldwide citation)

Attenuated stable influenza type B virus strains are obtained by recombining a vaccinal and previously attenuated influenza type B virus strain with an influenza type B virus isolate having the desired serotype and isolating a recombinant having at least one marker property of the attenuated parent ...


52
Kawaoka Yoshihiro, Hatta Masato: Neuraminidase-deficient live influenza vaccines. Kawaoka Yoshihiro, Hatta Masato, STEFFEY Charles E, December 4, 2008: WO/2008/147496 (4 worldwide citation)

Attenuated, neuraminidase deficient influenza virus, and compositions and methods to prepare that virus, are provided.


53
Vajdy Michael, O Hagan Derek: Adminstration routes for priming/boosting with influenza vaccines. Novartis Vaccines And Diagnostics, Vajdy Michael, O Hagan Derek, MARSHALL Cameron John, May 10, 2007: WO/2007/052057 (4 worldwide citation)

Patients receive a mucosal influenza vaccine and then receive a parenteral influenza vaccine, in that order, typically during different visits to a vaccination centre.


54
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, LAVOIE PIERRE OLIVIER, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE: PSEUDO-PARTICULES DU VIRUS DE LA GRIPPE (VLP) COMPRENANT DE LHEMAGGLUTININE (HA) PRODUIT DANS UNE PLANTE, INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, September 24, 2013: CA2693956 (4 worldwide citation)

A method for synthesizing influenza virus--like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pr ...


55
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE, LAVOIE PIERRE OLIVIER: PARTICULES PSEUDOVIRALES (VLP) DE LA GRIPPE RECOMBINEES PRODUITES DANS DES PLANTES TRANSGENIQUES EXPRIMANT LHEMAGGLUTININE, RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, November 19, 2013: CA2707235 (4 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


56
Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A: Modified influenza virus for monitoring and improving vaccine efficiency. St Jude Children S Research Hospital, Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A, LUDWIG S Peter, February 15, 2007: WO/2007/019094 (4 worldwide citation)

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by alt ...


57
Couture Manon, Vézina Louis Philippe, Landry Nathalie: New influenza virus immunizing epitope. Medicago, Couture Manon, Vézina Louis Philippe, Landry Nathalie, Ogilvy Renault Sencrl, January 21, 2010: WO/2010/006452 (4 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of a novel influenza HA protein in plants and its purification The invention is also directed towards a VLP comprising influenza HA protein and plants li ...


58
Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen: Method for producing temperature sensitive influenza A viruses. Medimmune, Grant Anderson, February 14, 2012: US08114415 (3 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


59
HOFFMAN ERICH, JIN HONG, LU BIN, DUKE GREG, KEMBLE GEORGE WILLIAM: SYSTEME MULTIPLASMIDE DE PRODUCTION DE VIRUS INFLUENZA, MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS. MEDIMMUNE VACCINES, MEDIMMUNE VACCINES, FETHERSTONHAUGH & CO, September 17, 2013: CA2482946 (3 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.


60
Minke Jules Maarten, Karaca Kemal, Yao Jiansheng: Canine influenza vaccines. Merial, Minke Jules Maarten, Karaca Kemal, Yao Jiansheng, JARECKI BLACK PHD JD Judy, March 1, 2007: WO/2007/024947 (3 worldwide citation)

The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens w ...