51
D Aoust Marc André, Couture Manon, Ors Frédéric, Trépanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vézina Louis Philippe, Landry Nathalie: (vlps) Produced in transgenic plants expressing hemagglutinin. Medicago, D Aoust Marc André, Couture Manon, Ors Frédéric, Trépanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vézina Louis Philippe, Landry Nathalie, SECHLEY Konrad A, June 25, 2009: WO/2009/076778 (3 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


52
Webb Steven Robert, Henry Matthew J: Vaccine for avian influenza and methods of use. Dow Agrosciences, Webb Steven Robert, Henry Matthew J, EISENSCHENK Frank C, May 22, 2008: WO/2008/060669 (3 worldwide citation)

The subject invention pertains to influenza vaccines and particularly avian influenza vaccines (AIV). The invention includes methods for preparing transgenic plant cells to express know HAl polypeptides having specified homologies that are used to prepare vaccine compositions and methods for inducin ...


53
Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A: Modified influenza virus for monitoring and improving vaccine efficiency. St Jude Children S Research Hospital, Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A, LUDWIG S Peter, February 15, 2007: WO/2007/019094 (3 worldwide citation)

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by alt ...


54
D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie: Influenza virus-like particles (vlps) comprising hemagglutinin. Medicago, D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie, Sechley Konrad A, January 14, 2010: WO/2010/003225 (3 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP ...


55
GALARZA JOSE: Universal virus-like particle (vlp) influenza vaccines. TECHNOVAX, Pasternak Dahna S, August 25, 2011: WO/2011/102900 (3 worldwide citation)

Described herein are influenza virus-like particles (VLPs) that display one or more truncated, re-engineered or remodeled HA molecules on their surface. Also described are methods of making and using these VLPs.


56
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, LAVOIE PIERRE OLIVIER, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE: PSEUDO-PARTICULES DU VIRUS DE LA GRIPPE (VLP) COMPRENANT DE LHEMAGGLUTININE (HA) PRODUIT DANS UNE PLANTE, INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, September 24, 2013: CA2693956 (3 worldwide citation)

A method for synthesizing influenza virus--like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pr ...


57
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE, LAVOIE PIERRE OLIVIER: PARTICULES PSEUDOVIRALES (VLP) DE LA GRIPPE RECOMBINEES PRODUITES DANS DES PLANTES TRANSGENIQUES EXPRIMANT LHEMAGGLUTININE, RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, November 19, 2013: CA2707235 (3 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


58
George Kemble, Gregory Duke: Multi plasmids system for the production of influenza virus. Medimmune, Grant Anderson, April 2, 2013: US08409843 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


59
Erich Hoffmann, Hong Jin, George Kemble, Zhongying Chen: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, November 5, 2013: US08574591 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


60
Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble: Multi plasmid system for the production of influenza virus. MedImmune, Grant IP, May 13, 2014: US08722059 (2 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.



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