41
Gregersen Jens Peter: Decreasing potential iatrogenic risks associated with influenza vaccines. Novartis Vaccines And Diagnostics & Co Kg, Gregersen Jens Peter, MARSHALL Cameron John, March 16, 2006: WO/2006/027698 (7 worldwide citation)

Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus 5 cult ...


42
De, Wit Emmie, Spronken Monique Ij, Fouchier Ron Am, Osterhaus Albert Dme: Rescue of influenza virus. Solvay Pharmaceuticals, Erasmus University Medical Center Rotterdam, de, Wit Emmie, Spronken Monique Ij, Fouchier Ron Am, Osterhaus Albert Dme, AERTS Robert J, June 29, 2006: WO/2006/067211 (6 worldwide citation)

The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens'eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. The invention provides a nucleic acid compri ...


43
George Kemble, Gregory Duke: Multi plasmids system for the production of influenza virus. Medimmune, Grant Anderson, April 2, 2013: US08409843 (5 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


44
Erich Hoffmann, Hong Jin, George Kemble, Zhongying Chen: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, November 5, 2013: US08574591 (5 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


45
Maria Grazia Pau, Alphonsus G C M UytdeHaag: Production of vaccines. Crucell Holland, TraskBritt, November 16, 2010: US07833788 (5 worldwide citation)

Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium ...


46
Maria Grazia Pau, Alphonsus G C M UytdeHaag, Govert Johan Schouten: Production of vaccines. Crucell Holland, TraskBritt, May 5, 2009: US07527961 (5 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...


47
Hibberd Patricia, Gorbach Sherwood, Snydman David, Goldin Barry: Compositions and methods for enhancing the efficacy of vaccines. New England Medical Center Hospitals, Tufts University, Hibberd Patricia, Gorbach Sherwood, Snydman David, Goldin Barry, CREWS Lee, November 23, 2006: WO/2006/124630 (5 worldwide citation)

This invention concerns compositions for enhancing the efficacy of vaccines such as influenza vaccines. Also included are kits that include these compositions and methods of using the compositions and kits to treat a subject.


48
Kawaoka Yoshihiro, Hatta Masato: Neuraminidase-deficient live influenza vaccines. Kawaoka Yoshihiro, Hatta Masato, STEFFEY Charles E, December 4, 2008: WO/2008/147496 (5 worldwide citation)

Attenuated, neuraminidase deficient influenza virus, and compositions and methods to prepare that virus, are provided.


49
Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle: Soluble recombinant influenza antigens. Medicago, Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle, Sechley Konrad A, January 14, 2010: WO/2010/003235 (5 worldwide citation)

The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal ...


50
Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen: Method for producing temperature sensitive influenza A viruses. Medimmune, Grant Anderson, February 14, 2012: US08114415 (4 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...