41
Maria Grazia Pau, Alphonsus G C M UytdeHaag: Production of vaccines. Crucell Holland, TraskBritt, June 23, 2009: US07550284 (4 worldwide citation)

Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium ...


42
Maria G Pau, Alphonsus G C M UytdeHaag, Govert J Schouten: Production of vaccines. Crucell Holland, TraskBritt, April 21, 2009: US07521220 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...


43
Julien Peetermans, Michele Lobmann, Jean Marie Prevost, Emil Vascoboinic: Live influenza type B virus vaccines and preparation thereof. Recherche et Industrie Therapeutiques, Alan D Lourie, William H Edgerton, June 8, 1976: US03962423 (4 worldwide citation)

Attenuated stable influenza type B virus strains are obtained by recombining a vaccinal and previously attenuated influenza type B virus strain with an influenza type B virus isolate having the desired serotype and isolating a recombinant having at least one marker property of the attenuated parent ...


44
Kawaoka Yoshihiro, Hatta Masato: Neuraminidase-deficient live influenza vaccines. Kawaoka Yoshihiro, Hatta Masato, STEFFEY Charles E, December 4, 2008: WO/2008/147496 (4 worldwide citation)

Attenuated, neuraminidase deficient influenza virus, and compositions and methods to prepare that virus, are provided.


45
Tsai Theodore F, Trusheim Heidi: Making influenza virus vaccines without using eggs. Novartis, Tsai Theodore F, Trusheim Heidi, MARSHALL Cameron John, March 20, 2008: WO/2008/032219 (4 worldwide citation)

Currently, the steps performed prior to release of influenza strains to vaccine manufacturers involve passaging influenza virus through eggs. The invention aims to provide procedures useful in manufacturing influenza vaccines, in which the use of eggs is reduced, and preferably is avoided altogether ...


46
Uytdehaag Alphonsus Gerardus Cornelis Maria, Pau Maria Grazia, Schouten Govert: Production influenza virus vaccines. Crucell Holland, Uytdehaag Alphonsus Gerardus Cornelis Maria, Pau Maria Grazia, Schouten Govert, HATEBOER Guus, April 26, 2007: WO/2007/045674 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of t he virus, and to form a virus-containing medium, and remov ...


47
Banzhoff Angelika, Clemens Ralf: Combined influenza vaccines for seasonal and pandemic protection. Novartis, Banzhoff Angelika, Clemens Ralf, Marshall Cameron John, December 17, 2009: WO/2009/150532 (4 worldwide citation)

Current approaches to influenza vaccination focus either on seasonal strains or pandemic strains. Current seasonal vaccines typically include antigens from two influenza A strains (H1N1 and H3N2) and one influenza B strain. Current pandemic vaccines focus on H5N1 influenza A virus strains. It is an ...


48
Vajdy Michael, O Hagan Derek: Adminstration routes for priming/boosting with influenza vaccines. Novartis Vaccines And Diagnostics, Vajdy Michael, O Hagan Derek, MARSHALL Cameron John, May 10, 2007: WO/2007/052057 (4 worldwide citation)

Patients receive a mucosal influenza vaccine and then receive a parenteral influenza vaccine, in that order, typically during different visits to a vaccination centre.


49
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, LAVOIE PIERRE OLIVIER, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE: PSEUDO-PARTICULES DU VIRUS DE LA GRIPPE (VLP) COMPRENANT DE LHEMAGGLUTININE (HA) PRODUIT DANS UNE PLANTE, INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, September 24, 2013: CA2693956 (4 worldwide citation)

A method for synthesizing influenza virus--like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pr ...


50
D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE, LAVOIE PIERRE OLIVIER: PARTICULES PSEUDOVIRALES (VLP) DE LA GRIPPE RECOMBINEES PRODUITES DANS DES PLANTES TRANSGENIQUES EXPRIMANT LHEMAGGLUTININE, RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, November 19, 2013: CA2707235 (4 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...



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