41
Maria Grazia Pau, Alphonsus G C M UytdeHaag, Govert Johan Schouten: Production of vaccines. Crucell Holland, TraskBritt, May 5, 2009: US07527961 (5 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...


42
Jens Peter Gregersen: Decreasing potential iatrogenic risks associated with influenza vaccines. Amy Hessler, Otis Littlefield, Robert J Gorman, February 21, 2012: US08119337 (5 worldwide citation)

Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realized that the conditions used for influenza virus 5 cult ...


43
Hibberd Patricia, Gorbach Sherwood, Snydman David, Goldin Barry: Compositions and methods for enhancing the efficacy of vaccines. New England Medical Center Hospitals, Tufts University, Hibberd Patricia, Gorbach Sherwood, Snydman David, Goldin Barry, CREWS Lee, November 23, 2006: WO/2006/124630 (5 worldwide citation)

This invention concerns compositions for enhancing the efficacy of vaccines such as influenza vaccines. Also included are kits that include these compositions and methods of using the compositions and kits to treat a subject.


44
D Aoust Marc André, Couture Manon, Ors Frédéric, Trépanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vézina Louis Philippe, Landry Nathalie: (vlps) Produced in transgenic plants expressing hemagglutinin. Medicago, D Aoust Marc André, Couture Manon, Ors Frédéric, Trépanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vézina Louis Philippe, Landry Nathalie, SECHLEY Konrad A, June 25, 2009: WO/2009/076778 (5 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


45
George Kemble, Gregory Duke: Multi plasmids system for the production of influenza virus. Medimmune, Grant Anderson, April 2, 2013: US08409843 (4 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


46
Erich Hoffmann, Hong Jin, George Kemble, Zhongying Chen: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, November 5, 2013: US08574591 (4 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


47
Maria Grazia Pau, Alphonsus G C M UytdeHaag: Production of vaccines. Crucell Holland, TraskBritt, November 16, 2010: US07833788 (4 worldwide citation)

Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium ...


48
Maria G Pau, Alphonsus G C M UytdeHaag, Govert J Schouten: Production of vaccines. Crucell Holland, TraskBritt, June 21, 2011: US07964198 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...


49
Maria Grazia Pau, Alphonsus G C M UytdeHaag: Production of vaccines. Crucell Holland, TraskBritt, June 23, 2009: US07550284 (4 worldwide citation)

Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium ...


50
Maria G Pau, Alphonsus G C M UytdeHaag, Govert J Schouten: Production of vaccines. Crucell Holland, TraskBritt, April 21, 2009: US07521220 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...