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Ben Yedidia Tamar, Singer Yossi: Multimeric multiepitope influenza vaccines. Biondvax Pharmaceuticals, Ben Yedidia Tamar, Singer Yossi, WEBB PO Box 2189 76121 Rehovot, February 5, 2009: WO/2009/016639 (7 worldwide citation)

The present invention relates to multimeric multi-epitope peptide-based vaccines. In particular, the present invention relates to the use of multimeric multi-epitope peptide-based vaccines eliciting protective immunity to influenza.


32
D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie: Influenza virus-like particles (vlps) comprising hemagglutinin. Medicago, D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie, Sechley Konrad A, January 14, 2010: WO/2010/003225 (7 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP ...


33
De, Wit Emmie, Spronken Monique Ij, Fouchier Ron Am, Osterhaus Albert Dme: Rescue of influenza virus. Solvay Pharmaceuticals, Erasmus University Medical Center Rotterdam, de, Wit Emmie, Spronken Monique Ij, Fouchier Ron Am, Osterhaus Albert Dme, AERTS Robert J, June 29, 2006: WO/2006/067211 (6 worldwide citation)

The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens'eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. The invention provides a nucleic acid compri ...


34
Gregersen Jens Peter: Decreasing potential iatrogenic risks associated with influenza vaccines. Novartis Vaccines And Diagnostics & Co Kg, Gregersen Jens Peter, MARSHALL Cameron John, March 16, 2006: WO/2006/027698 (6 worldwide citation)

Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus 5 cult ...


35
YUSIBOV VIDADI: Influenza vaccines, antigens, compositions, and methods. FRAUNHOFER USA, Phillips Eifion, April 1, 2010: WO/2010/036970 (6 worldwide citation)

The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and compositions useful in inducing or enhancing an immune response agains influenza antigens. Provided are recombinant protein antigens, compositions, and methods for ...


36
George Kemble, Gregory Duke: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, January 10, 2012: US08093033 (5 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


37
Maria Grazia Pau, Alphonsus G C M UytdeHaag, Govert Johan Schouten: Production of vaccines. Crucell Holland, TraskBritt, May 5, 2009: US07527961 (5 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...


38
Hibberd Patricia, Gorbach Sherwood, Snydman David, Goldin Barry: Compositions and methods for enhancing the efficacy of vaccines. New England Medical Center Hospitals, Tufts University, Hibberd Patricia, Gorbach Sherwood, Snydman David, Goldin Barry, CREWS Lee, November 23, 2006: WO/2006/124630 (5 worldwide citation)

This invention concerns compositions for enhancing the efficacy of vaccines such as influenza vaccines. Also included are kits that include these compositions and methods of using the compositions and kits to treat a subject.


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COUTURE MANON: Chimeric influenza virus-like particles comprising hemagglutinin. MEDICAGO, Sechley Konrad A, December 29, 2010: WO/2010/148511 (5 worldwide citation)

A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA prote ...


40
Maria G Pau, Alphonsus G C M UytdeHaag, Govert J Schouten: Production of vaccines. Crucell Holland, TraskBritt, June 21, 2011: US07964198 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removi ...



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