21
Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen: Multi plasmid system for the production of influenza virus. MedImmune, December 16, 2008: US07465456 (10 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


22
Abraham Sestel Beare, David Arthur John Tyrrell, David McCahon: Influenza vaccines. Donald Brown, November 9, 1976: US03991179 (10 worldwide citation)

A recombinant influenza virus strain derived from (a) an over-attenuated influenza A strain which has been passaged solely in chicken egg cultures, manifests a relatively high yield of virus in such cultures and has an increased capacity for plaque formation on calf kidney cells and (b) a virulent i ...


23
Ben Yedidia Tamar, Arnon Ruth: Improved influenza vaccine. Yeda Research And Development At The Weizmann Institute Of Science, Ben Yedidia Tamar, Arnon Ruth, WEBB Cynthia, June 14, 2007: WO/2007/066334 (9 worldwide citation)

The present invention relates in general to influenza vaccines for human and veterinary use. In particular, the present invention provides a vaccine able to effect long term and cross-strain protection comprising at least two influenza virus epitopes expressed as aa chimeric polypeptide wherein at l ...


24
Hermann Katinger, Andre Egorov, Boris Ferko, Julia Romanova, Dietmar Katinger: Live attenuated influenza vaccine. Polymun Scientific Immunbiologische Forschung, Ostrolenk Faber Gerb & Soffen, February 24, 2009: US07494659 (8 worldwide citation)

The invention relates to a simple and efficient process for isolating viruses from various sources and for producing live attenuated influenza vaccines in a serum-free Vero cell culture under conditions where alterations in the surface antigens of the virus due to adpative selection are minimized or ...


25
Broeker Michael, Kost Holger: Influenza vaccines containing hemagglutinin and matrix proteins. Novartis Vaccines And Diagnostics & Co Kg, Broeker Michael, Kost Holger, MARSHALL Cameron John, August 2, 2007: WO/2007/085969 (8 worldwide citation)

An immunogenic composition comprising influenza virus haemagglutinin and matrix proteins. These may be from influenza viruses grown in cell culture rather than eggs. The matrix protein may be a fragment of a full-length viral matrix protein e.g. a matrix M1 fragment with a molecular weight of less t ...


26
D Aoust Marc André, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie: (vlps) Comprising hemagglutinin produced within a plant. Medicago, D Aoust Marc André, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie, SECHLEY Konrad A, January 22, 2009: WO/2009/009876 (8 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


27
Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, September 6, 2011: US08012736 (7 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.


28
Sabine Neirynck, Willy Min Jou, Walter Fiers: Immunoprotective influenza antigen and its use in vaccination. Vlaams Interuniversitair Instituut Voor Biotechnologie, Husch Blackwell Sanders, June 8, 2010: US07731972 (7 worldwide citation)

The present invention relates to an influenza antigen, comprising a fusion product of at least (1) the extracellular part of a conserved influenza membrane protein (e.g., M2) or a functional equivalent thereof and (2) a presenting carrier. The presenting carrier may be a (poly)peptide or a non-pepti ...


29
De, Wit Emmie, Spronken Monique Ij, Fouchier Ron Am, Osterhaus Albert Dme: Rescue of influenza virus. Solvay Pharmaceuticals, Erasmus University Medical Center Rotterdam, de, Wit Emmie, Spronken Monique Ij, Fouchier Ron Am, Osterhaus Albert Dme, AERTS Robert J, June 29, 2006: WO/2006/067211 (6 worldwide citation)

The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens'eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. The invention provides a nucleic acid compri ...


30
Gregersen Jens Peter: Decreasing potential iatrogenic risks associated with influenza vaccines. Novartis Vaccines And Diagnostics & Co Kg, Gregersen Jens Peter, MARSHALL Cameron John, March 16, 2006: WO/2006/027698 (6 worldwide citation)

Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus 5 cult ...



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