21
New vaccines for combating influenza and the preparation thereof. Rhone Poulenc, March 11, 1970: GB1183506-A (12 worldwide citation)

1,183,506. Influenza vaccines. RHONEPOULENC S.A. 20 Nov., 1967 [21 Nov., 1966], No. 52684/67. Heading A5B. Inactivated influenza virus suspensions are prepared by culturing the one or more strains of influenza virus in the allantoic cavity of an embryonated chicken egg, purifying the virus by differ ...


22
Maria Grazia Pau, Alphonsus G C M UytdeHaag: Production of vaccines. Crucell Holland, Trask Britt, March 20, 2007: US07192759 (11 worldwide citation)

Novel means and methods are provided for the production of mammalian viruses comprising, infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...


23
Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, September 6, 2011: US08012736 (10 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.


24
Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen: Multi plasmid system for the production of influenza virus. MedImmune, December 16, 2008: US07465456 (10 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


25
Abraham Sestel Beare, David Arthur John Tyrrell, David McCahon: Influenza vaccines. Donald Brown, November 9, 1976: US03991179 (10 worldwide citation)

A recombinant influenza virus strain derived from (a) an over-attenuated influenza A strain which has been passaged solely in chicken egg cultures, manifests a relatively high yield of virus in such cultures and has an increased capacity for plaque formation on calf kidney cells and (b) a virulent i ...


26
Ben Yedidia Tamar, Arnon Ruth: Improved influenza vaccine. Yeda Research And Development At The Weizmann Institute Of Science, Ben Yedidia Tamar, Arnon Ruth, WEBB Cynthia, June 14, 2007: WO/2007/066334 (9 worldwide citation)

The present invention relates in general to influenza vaccines for human and veterinary use. In particular, the present invention provides a vaccine able to effect long term and cross-strain protection comprising at least two influenza virus epitopes expressed as aa chimeric polypeptide wherein at l ...


27
Contorni Mario: Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant. Novartis Vaccines And Diagnostics, Contorni Mario, MARSHALL Cameron John, May 10, 2007: WO/2007/052155 (9 worldwide citation)

Influenza vaccines with oil-in-water emulsion adjuvants are known. The amount of emulsion adjuvant required for an influenza vaccine can be reduced, thereby allowing more vaccines to be made from a given amount of emulsion, and/or minimizing the amount of emulsion that has to be produced for a given ...


28
Ben Yedidia Tamar, Singer Yossi: Multimeric multiepitope influenza vaccines. Biondvax Pharmaceuticals, Ben Yedidia Tamar, Singer Yossi, WEBB PO Box 2189 76121 Rehovot, February 5, 2009: WO/2009/016639 (9 worldwide citation)

The present invention relates to multimeric multi-epitope peptide-based vaccines. In particular, the present invention relates to the use of multimeric multi-epitope peptide-based vaccines eliciting protective immunity to influenza.


29
COUTURE MANON: Chimeric influenza virus-like particles comprising hemagglutinin. MEDICAGO, Sechley Konrad A, December 29, 2010: WO/2010/148511 (9 worldwide citation)

A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA prote ...


30
George Kemble, Gregory Duke: Multi plasmid system for the production of influenza virus. Medimmune, Grant Anderson, January 10, 2012: US08093033 (8 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...