1
George S Wilson, Dilbir S Bindra, Brian S Hill, Daniel R Thevenot, Robert Sternberg, Gerard Reach, Yanan Zhang: Implantable glucose sensor. The University of Kansas, Hovey Williams Timmons & Collins, November 24, 1992: US05165407 (1001 worldwide citation)

Implantable enzymatic sensors (25, 43, 44) for biochemicals such as glucose are provided having an ideal size and geometry for optional long term implantation and linear responses over the concentration ranges of interest. The sensors (25, 43, 44) include an elongated body (10, 26, 46) supporting an ...


2
W Kenneth Ward, Eric S Wilgus: Device for monitoring changes in analyte concentration. Kolisch Hartwell Dickinson McCormack & Heuser, January 27, 1998: US05711861 (758 worldwide citation)

The invention provides an electrochemical sensor system for measuring analyte concentrations in a sample fluid. The invention is particularly useful for measuring analytes such as glucose in a patient. An implantable glucose sensor includes a disc-shaped body containing multiple anodes on opposing s ...


3
Samuel P Bessman, Ennis C Layne, Lyell J Thomas: Implantable glucose sensor. Fidelman Wolffe & Waldron, February 14, 1984: US04431004 (740 worldwide citation)

A method and apparatus for more accurate measurements of the glucose content in body fuids by sensing the absolute level of oxygen concentration in the fluid and correcting the output differential measurement indicative of the glucose content in the fluid according to the absolute level of oxygen.


4
James H Brauker, Victoria Carr Brendel, Paul V Neale, Laura A Martinson, Mark A Tapsak: Optimized sensor geometry for an implantable glucose sensor. DexCom, Knobbe Martens Olson & Bear, November 14, 2006: US07134999 (736 worldwide citation)

An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such tha ...


5
W Kenneth Ward, Eric S Wilgus: Device for monitoring changes in analyte concentration. Good Samaritan Hospital and Medical Center, Stoel Rives, April 3, 2001: US06212416 (670 worldwide citation)

The invention provides an electrochemical sensor system for measuring analyte concentrations in a fluid sample. The invention is particularly useful for measuring analytes such as glucose in a patient. An implantable glucose sensor includes a disc-shaped sensor body containing multiple anodes on opp ...


6
Ebtisam S Wilkins: Vivo refillable glucose sensor. The University of New Mexico, Albert Sopp, January 22, 1991: US04986271 (431 worldwide citation)

An arrangement for prolonging the useful life of an electrochemical refillable implantable glucose sensor employing an enzyme material such as glucose oxidase immobilized on bulk particulate matter suspended in a fluid for reaction with components of bodily fluids and which enzyme material when exha ...


7
W Kenneth Ward, Eric S Wilgus: Implantable device for monitoring changes in analyte concentration. Legacy Good Samaritan Hospital and Medical Center, Stoel Rives, October 15, 2002: US06466810 (414 worldwide citation)

The invention provides an electrochemical sensor system for measuring analyte concentrations in a fluid sample. The invention is particularly useful for measuring analytes such as glucose in a patient. An implantable glucose sensor includes a disc-shaped sensor body containing multiple anodes on opp ...


8
Leland C Clark Jr: Implantable glucose sensor. Implanted Biosystems, Crosby Heafey Roach & May, January 29, 2002: US06343225 (335 worldwide citation)

The sensitivity of enzyme-based polarographic electrodes to oxygen concentration can be significantly reduced or eliminated by providing an oxygen-reservoir in intimate contact with the oxidative enzyme. This is achieved by making a stabilized emulsion between the enzyme and a compound in which oxyg ...


9
Leland C Clark Jr: Implantable glucose sensor. Implanted Biosystems, Liner Yankelevitz Sunshine and Regenstreif, November 9, 2004: US06815186 (297 worldwide citation)

The sensitivity of enzyme-based polarographic electrodes to oxygen concentration can be significantly reduced or eliminated by providing an oxygen-reservoir in intimate contact with the oxidative enzyme. This is achieved by making a stabilized emulsion between the enzyme and a compound in which oxyg ...


10
Ebtisam Wilkins: Membrane electrode for non-ionic species. University Patents, George M Yahwak, April 3, 1984: US04440175 (289 worldwide citation)

Concentrations of non-ionic species in aqueous media are measured as a function of potentiometric or polarographic response, employing a membrane electrode selective for the non-ionic species being measured. The electrode comprises a conductive substrate and a membrane formed as a layer on the condu ...